ArticleScientific reports2017
Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Myotube/Adipocyte Powder-Enriched Alginate-Zein Hydrogels Support Myotube Alignment for 3D Myoblast Culture.Foods (Basel, Switzerland) · 2026Article
- Biocompatible, Ion-Conductive Hydrogel-Filled Nerve Conduit for Peripheral Nerve Regeneration.ACS applied materials & interfaces · 2026Article
- Emerging Smart and Adaptive Hydrogels for Next-Generation Tissue Engineering.Bioengineering (Basel, Switzerland) · 2025Review
- Bicontinuous Interconnected Porous Biomaterials for Tissue Engineering and Regeneration.Small science · 2025Article
- Mechanically Robust and Conductive Gelatin/Glucose Hydrogels Enabled by the Hofmeister Effect for Flexible Strain Sensors.Gels (Basel, Switzerland) · 2025Article
- Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering.Bioactive materials · 2025Review
- Influence of Surface Texture in Additively Manufactured Biocompatible Materials and Triboelectric Behavior.Materials (Basel, Switzerland) · 2025Review
- Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair.Bioactive materials · 2025Review
- Electrical and magnetic stimulation separately modulates the extent and direction of neurite outgrowth in an ionically conductive hydrogel.Journal of neural engineering · 2025Article
- Stimuli-Responsive Self-Healing Ionic Gels: A Promising Approach for Dermal and Tissue Engineering Applications.ACS biomaterials science & engineering · 2025Review
- Design of PEG-Based Hydrogels as Soft Ionic Conductors.Journal of biomedical materials research. Part A · 2025Article
- A stretchable, electroconductive tissue adhesive for the treatment of neural injury.Bioengineering & translational medicine · 2024Article
- Recent Progress in Artificial Neurons for Neuromodulation.Journal of functional biomaterials · 2024Review
- Electroconductive agarose hydrogels modulate mesenchymal stromal cell adhesion and spreading through protein adsorption.Journal of biomedical materials research. Part A · 2023Article
- Complex Material Properties of Gel-Amin: A Transparent and Ionically Conductive Hydrogel for Neural Tissue Engineering.Cells, tissues, organs · 2023Article
- Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Advanced Formulations Based on Poly(ionic liquid) Materials for Additive Manufacturing.Polymers · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional methods to engineer electroconductive hydrogels (ECHs) through the incorporation of conductive nanomaterials and polymers exhibit major technical limitations. These are mainly associated with the cytotoxicity, as well as poor solubility, processability, and biodegradability of their components. Here, we describe the engineering of a new class of ECHs through the functionalization of non-conductive polymers with a conductive choline-based bio-ionic liquid (Bio-IL). Bio-IL conjugated hydrogels exhibited a wide range of highly tunable physical properties, remarkable in vitro and in vivo biocompatibility, and high electrical conductivity without the need for additional conductive components. The engineered hydrogels could support the growth and function of primary cardiomyocytes in both two dimentinal (2D) and three dimensional (3D) cultures in vitro. Furthermore, they were shown to be efficiently biodegraded and possess low immunogenicity when implanted subcutaneously in rats. Taken together, our results suggest that Bio-IL conjugated hydrogels could be implemented and readily tailored to different biomedical and tissue engineering applications.
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Registered trials
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