Evidence map›Paper›PMID 28659615›Full record

ArticleScientific reports2017

K

L Robles-Martínez, E Garay, M G Martel-Gallegos, A Cisneros-Mejorado, D Pérez-Montiel, A Lara, R O Arellano

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Purinergic Signaling in Ovarian Carcinoma.Advanced pharmaceutical bulletin · 2025
    Review
  2. Review
  3. Targeting purine metabolism in ovarian cancer.Journal of ovarian research · 2022
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. P2Y2 purinergic receptor modulates virus yield, calcium homeostasis, and cell motility in human cytomegalovirus-infected cells.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

L Robles-MartínezDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla Querétaro, CP 76230, Querétaro, México, Mexico.
E GarayDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla Querétaro, CP 76230, Querétaro, México, Mexico.
M G Martel-GallegosDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla Querétaro, CP 76230, Querétaro, México, Mexico.
A Cisneros-MejoradoDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla Querétaro, CP 76230, Querétaro, México, Mexico.
D Pérez-MontielDepartamento de Patología, Instituto Nacional de Cancerología, Secretaría de Salud, Av. San Fernando #22, Colonia Sección XVI, Tlalpan, CP 14080, Ciudad de México, México, Mexico.
A LaraDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla Querétaro, CP 76230, Querétaro, México, Mexico.
R O ArellanoDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, Juriquilla Querétaro, CP 76230, Querétaro, México, Mexico. arellano.ostoa@comunidad.unam.mx.ORCID 0000-0002-8646-250X
Universidad Nacional Autónoma de México · MXAutonomous University of Queretaro · MXSecretaria de Salud · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders in cell signaling mediated by ATP or histamine, activating specific membrane receptors, have been frequently associated with tumorigenesis. Among the elements of response to purinergic (and histaminergic) signaling, ion channel activation controls essential cellular processes in cancer, such as cell proliferation, motility, and death. Here, we studied the effects that ATP had on electrical properties of human ovarian adenocarcinoma cells named SKOV-3. ATP caused increase in intracellular Ca

Indexed as

Ion Channel GatingAdenosine TriphosphateCalciumCalcium SignalingCell Line, TumorCell MovementCell ProliferationDose-Response Relationship, DrugFemaleGene ExpressionGene SilencingHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsIonsMembrane PotentialsOvarian NeoplasmsAdenosine TriphosphateCalciumIntermediate-Conductance Calcium-Activated Potassium ChannelsIonsKCNN4 protein, humanPotassium Channel BlockersReceptors, Purinergic P2Y2RNA, Small Interfering

Identifiers

PMID28659615
PMCPMC5489490
OpenAlexW2712733682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.