ArticleExperimental animals2017
An alert of Mycobacterium tuberculosis infection of rhesus macaques in a wild zoo in China.
Article in Experimental animals, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Incidental transmural granulomatous enteritis caused by Molineus torulosus in a capuchin monkey (Sapajus nigritus) under human care: pathological and morphometric findings.Veterinary research communications · 2026Article
- The first visually-guided bronchoscopy in European bison (Bison bonasus) - An additional tool in the diagnosis of bovine tuberculosis?Veterinary and animal science · 2021Article
- Characterization of the Gut Microbiome and Resistomes of Wild and Zoo-Captive Macaques.Frontiers in veterinary science · 2021Article
- Mycobacterium tuberculosis var. tuberculosis infection in two captive black capuchins (Sapajus nigritus) in Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis.BioMed research international · 2020Review
- Long-Tailed Macaques (The American journal of tropical medicine and hygiene · 2019Article
- Identification of Moraxella lacunata from pulmonary abscesses in three zoo herbivores.The Journal of veterinary medical science · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB), is becoming increasingly recognized as an important cause of fatal chronic illnesses in China. In this study, we report an infectious disease among 84 rhesus macaques at a Chinese zoo. Their clinical signs and symptoms were very similar with the manifestations of TB in humans. To determine the potential pathogens of this outbreak, many methods were used. First, tuberculin skin tests showed that none of the monkeys displayed significant skin reactions. Subsequently, the sera were tested for specific antibody IgG; 29 (34.5%) and 39 (46.4%) blood samples tested positive by TB-IgG and TB-DOT, respectively. Radiographic examination showed characteristic imageology changes in 14 (16.7%) monkeys. One individual determined as positive by the above three methods was euthanized, and histopathological analysis demonstrated typical granulomas and caseous necrosis in the lung, liver, spleen, and intestine. Furthermore, the pathogenic mycobacteria were isolated from lung lobe, cultured on acidic Lowenstein-Jensen culture medium, and identified as M. tuberculosis by real-time PCR and DNA sequencing. Nevertheless, the origin of the infection remained unknown. These findings emphasize the need to strengthen the management and training of staff, especially those working at animal shelters.
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