Evidence map›Paper›PMID 28659507›Full record

ArticleAging2017

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.

Quynh Nhu Dinh, Grant R Drummond, Barbara K Kemp-Harper, Henry Diep, T Michael De Silva, Hyun Ah Kim, Antony Vinh, Avril A B Robertson, Matthew A Cooper, Ashley Mansell and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives.International journal of molecular sciences · 2023
    Review
  7. Hallmarks of cardiovascular ageing.Nature reviews. Cardiology · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Pressure-Natriuresis Response Is Diminished in Old Age.Frontiers in cardiovascular medicine · 2022
    Article
  12. Article
  13. Article
  14. Vascular Stress Signaling in Hypertension.Circulation research · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Oxidative Stress: A Unifying Paradigm in Hypertension.The Canadian journal of cardiology · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Quynh Nhu DinhCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Grant R DrummondCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Barbara K Kemp-HarperCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Henry DiepCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
T Michael De SilvaCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Hyun Ah KimCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Antony VinhCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Avril A B RobertsonThe Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia.
Matthew A CooperThe Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia.
Ashley MansellHudson Institute of Medical Research, Victoria, Australia.
Sophocles ChrissobolisCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Christopher G SobeyCardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia.
Monash University · AUAustralian Regenerative Medicine Institute · AULa Trobe University · AUUniversity of Queensland · AUHudson Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d. Aging increased renal but not brain expression of Ang II receptors (

Indexed as

AgingAngiotensin IIAnimalsBiomarkersBlood PressureBrainGene Expression RegulationInflammationKidneyMaleMesenteric ArteriesMiceMice, Inbred C57BLOxidative StressVasoconstrictionAngiotensin IIBiomarkersagingangiotensin IIhypertensioninflammationoxidative stressvasoconstriction

Identifiers

PMID28659507
PMCPMC5509458
OpenAlexW2728456157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.