Evidence map›Paper›PMID 28659487›Full record

ArticleJournal of virology2017

Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes.

Stephanie Franz, Paul Rennert, Maria Woznik, Josephine Grützke, Amy Lüdde, Eva Maria Arriero Pais, Tim Finsterbusch, Henriette Geyer, Annette Mankertz, Nicole Friedrich

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Alveolar macrophages are early targets of mumps virus.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Small hydrophobic (SH) proteins ofJournal of virology · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Regulation of cGAS-Mediated Immune Responses and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Stephanie FranzRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Paul RennertRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Maria WoznikRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Josephine GrützkeRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Amy LüddeRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Eva Maria Arriero PaisRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Tim FinsterbuschRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Henriette GeyerRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Annette MankertzRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany.
Nicole FriedrichRobert Koch Institute, Unit 12, Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients, Berlin, Germany friedrichn@rki.de.
Robert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mumps virus (MuV) small hydrophobic protein (SH) is a type I membrane protein expressed in infected cells. SH has been reported to interfere with innate immunity by inhibiting tumor necrosis factor alpha (TNF-α)-mediated apoptosis and NF-κB activation. To elucidate the underlying mechanism, we generated recombinant MuVs (rMuVs) expressing the SH protein with an N-terminal FLAG epitope or lacking SH expression due to the insertion of three stop codons into the

Indexed as

Host-Pathogen InteractionsAnimalsCell LineHumansMumps virusNF-kappa BReceptors, Interleukin-1 Type IReceptors, Tumor Necrosis Factor, Type IToll-Like Receptor 3Viral ProteinsIL1R1 protein, humanNF-kappa BReceptors, Interleukin-1 Type IReceptors, Tumor Necrosis Factor, Type Ismall hydrophobic protein, Mumps virusTLR3 protein, humanToll-Like Receptor 3Viral ProteinsmumpsNF-κBparamyxovirus

Identifiers

PMID28659487
PMCPMC5571265
OpenAlexW2727486813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.