ArticleJournal of neurophysiology2017
Caffeine accelerates recovery from general anesthesia via multiple pathways.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of Caffeine on the Acceleration of Emergence from General Anesthesia with Inhalation Anesthetics in Children Undergoing Inguinal Herniorrhaphy: A Randomized Clinical Trial.Iranian journal of medical sciences · 2022Trial
- Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study.Anesthesiology · 2018Trial
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents.Anesthesiology · 2024Article
- Activation of astrocytes in the basal forebrain in mice facilitates isoflurane-induced loss of consciousness and prolongs recovery.BMC anesthesiology · 2023Article
- Ketone supplementation abolished isoflurane anesthesia-induced elevation in blood glucose level and increased recovery time from anesthesia in Wistar Albino Glaxo Rijswijk rats.BMC anesthesiology · 2023Article
- Caffeine Use in the Anesthetic Management of a Patient With Congenital Central Hypoventilation.Cureus · 2022Article
- Historical and Modern Evidence for the Role of Reward Circuitry in Emergence.Anesthesiology · 2022Review
- Respiratory depression in the post-anesthesia care unit: Mayo Clinic experience.Bosnian journal of basic medical sciences · 2021Review
- Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.BMC anesthesiology · 2021Article
- Neurotransmitter networks in mouse prefrontal cortex are reconfigured by isoflurane anesthesia.Journal of neurophysiology · 2020Article
- Caffeine reverses the unconsciousness produced by light anesthesia in the continued presence of isoflurane in rats.PloS one · 2020Article
- Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia.Anesthesia and analgesia · 2019Review
- Effects of caffeine administration on sedation and respiratory parameters in patients recovering from anesthesia.Bosnian journal of basic medical sciences · 2018Article
- Comparison of the effects of caffeine, aminophylline, and saline on the recovery from total intravenous anesthesia in laparoscopic surgeries: A randomized controlled trial.Journal of anaesthesiology, clinical pharmacologyArticle
- Caffeine - Essentials for anaesthesiologists: A narrative review.Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Various studies have explored different ways to speed emergence from anesthesia. Previously, we have shown that three drugs that elevate intracellular cAMP (forskolin, theophylline, and caffeine) accelerate emergence from anesthesia in rats. However, our earlier studies left two main questions unanswered. First, were cAMP-elevating drugs effective at all anesthetic concentrations? Second, given that caffeine was the most effective of the drugs tested, why was caffeine more effective than forskolin since both drugs elevate cAMP? In our current study, emergence time from anesthesia was measured in adult rats exposed to 3% isoflurane for 60 min. Caffeine dramatically accelerated emergence from anesthesia, even at the high level of anesthetic employed. Caffeine has multiple actions including blockade of adenosine receptors. We show that the selective A
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.