ArticleNeurology2017
Slowing gait and risk for cognitive impairment: The hippocampus as a shared neural substrate.
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Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 5 of them syntheses that pooled it.
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97citing papers in PubMed, 5 pooled it
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Who cites it
97 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The association between sarcopenia and cognitive impairment in hospitalized older adults: a systematic review.BMC geriatrics · 2025Pooled it
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Associations of olfactory function with brain structural and functional outcomes. A systematic review.Ageing research reviews · 2023Pooled it
- Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2022Pooled it
- Dual-Task Gait as a Predictive Tool for Cognitive Impairment in Older Adults: A Systematic Review.Frontiers in aging neuroscience · 2021Pooled it
- Community-based assisted screening for mild cognitive impairment using gait and handwriting kinematic parameters analysis.World journal of psychiatry · 2025Trial
- Olfactory dysfunction is associated with gait impairment in older adults: evidence for a shared amygdala substrate.GeroScience · 2026Article
- Physical function domain associations with cognitive domains in community-dwelling older adults.medRxiv : the preprint server for health sciences · 2026Article
- Impact of Sleep Quality on Gait Variability: Pilot Cohort Study.JMIR aging · 2026Article
- Multidimensional modeling of biological aging: integrating gait, eye movement, rest-state functional connectivity, and plasma biomarkers in non-dementia older adults.The journal of prevention of Alzheimer's disease · 2026Article
- Real-world walking patterns are associated with regional brain atrophy and white matter lesions in middle-aged and older people: a Watch Walk-UK Biobank study.GeroScience · 2026Article
- Motor, Cognitive, Psychological, and Neural Predictors of Concern About Falling in Persons With Multiple Sclerosis.Neurorehabilitation and neural repair · 2026Article
- Cognition and brain network connectivity in timed up & go performance.GeroScience · 2026Article
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- Exploring Exercise-Linked Neurovascular Unit Adaptations and Sema3G Pathway Involvement in Rats with Vascular Cognitive Impairment.Neurochemical research · 2026Article
- Associations between independent or concurrent decline in upper and lower limb strength and cognitive impairment.BMC geriatrics · 2026Article
- An integrative approach to detecting potential blood-based biomarkers of cognitive frailty.The journal of nutrition, health & aging · 2026Observational
- Causal Effects Between Neurodegenerative Diseases, Metabolites, and Brain Volume.Current Alzheimer research · 2026Article
- Brain over muscle: central mechanisms predominate in gait impairment among older adults with type 2 diabetes mellitus.Frontiers in aging neuroscience · 2026Article
- Physical frailty and MRI markers of structural brain integrity in the community-dwelling late middle-aged and old adults.Scientific reports · 2025Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Andrea L RossoFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD. alr143@pitt.edu.
Joe VergheseFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Andrea L MettiFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Robert M BoudreauFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Howard J AizensteinFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Stephen KritchevskyFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Tamara HarrisFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Kristine YaffeFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Suzanne SatterfieldFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Stephanie StudenskiFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Caterina RosanoFrom the Department of Epidemiology (A.L.R., A.L.M., R.M.B., C.R.), School of Public Health, and Departments of Psychiatry and Bioengineering (H.J.A.), University of Pittsburgh, PA; Department of Neurology and Medicine (J.V.), Albert Einstein College of Medicine, Bronx, NY; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.B.K.), Wake Forest School of Medicine, Winston-Salem, NC; Laboratory of Epidemiology and Population Sciences (T.B.H.), IRP, National Institute on Aging, NIH, Bethesda, MD; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; Department of Preventive Medicine (S. Satterfield), University of Tennessee Health Science Center, Memphis; and Longitudinal Studies Section (S. Studenski), National Institute on Aging, Baltimore, MD.
Funding
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DALANE W KITZMAN · 2002 to 2026
$36.4MVARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6MCore-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3MUniversity of Pittsburgh Clinical and Translational Science InstitutionKL2TR000146 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$8.7MHealth, Aging and Body Composition StudyZIAAG007390 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2024
$4.0MPeripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5MNovel Brain Neuroimaging Markers of Age-Related Mobility ImpairmentK23AG028966 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSANO, CATERINA · 2006 to 2008
$643kEnvironmental Challenges and the Aging Brain: Implications for Community MobilityK01AG053431 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSSO, ANDREA L · 2016 to 2020
$509kNCATS NIH HHS KL2 TR000146NCATS NIH HHS UL1 TR001073NIA NIH HHS K01 AG053431NIA NIH HHS K23 AG028966NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG028050
Abstract
objectiveTo identify the shared neuroimaging signature of gait slowing and cognitive impairment.
methodsWe assessed a cohort of older adults (n = 175, mean age 73 years, 57% female, 65% white) with repeated measures of gait speed over 14 years, MRI for gray matter volume (GMV) at year 10 or 11, and adjudicated cognitive status at year 14. Gait slowing was calculated by bayesian slopes corrected for intercepts, with higher values indicating faster decline. GMV was normalized to intracranial volume, with lower values indicating greater atrophy for 10 regions of interest (hippocampus, anterior and posterior cingulate, primary and supplementary motor cortices, posterior parietal lobe, middle frontal lobe, caudate, putamen, pallidum). Nonparametric correlations adjusted for demographics, comorbidities, muscle strength, and knee pain assessed associations of time to walk with GMV. Logistic regression models calculated odds ratios (ORs) of gait slowing with dementia or mild cognitive impairment with and without adjustment for GMV.
resultsGait slowing was associated with cognitive impairment at year 14 (OR per 0.1 s/y slowing 1.47; 95% confidence interval 1.04-2.07). The right hippocampus was the only region that was related to both gait slowing (ρ = -0.16,
conclusionsThe association between gait slowing and cognitive impairment is supported by a shared neural substrate that includes a smaller right hippocampus. This finding underscores the value of long-term gait slowing as an early indicator of dementia risk.
Indexed as
AgedApolipoproteins EArthralgiaAtrophyCognitive DysfunctionComorbidityFemaleFollow-Up StudiesFunctional LateralityGait Disorders, NeurologicGray MatterHippocampusHumansKnee JointMagnetic Resonance ImagingMaleApolipoproteins E
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