Evidence map›Paper›PMID 28659379›Full record

ArticleThe EMBO journal2017

Glutamine fuels proliferation but not migration of endothelial cells.

Boa Kim, Jia Li, Cholsoon Jang, Zoltan Arany

Open access · greenAbstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 1 synthesis or guideline pooled it, 239 citations in OpenAlex.

  1. Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021
    Pooled it
  2. Article
  3. Review
  4. Excess glutamine rewires endothelial cell metabolism.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Amino acids: Missing link in preeclampsia pathogenesis?European journal of nutrition · 2026
    Observational
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Single-Cell Metabolic Imaging Reveals Glycogen-Driven Adaptations in Endothelial Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. L-Glutamine attenuates peritoneal fibrosis developed in 5-Fluorouracil-treated mice.Experimental biology and medicine (Maywood, N.J.) · 2026
    Article

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Boa KimDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jia LiDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cholsoon JangDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zoltan AranyDepartment of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA zarany@mail.med.upenn.edu.ORCID 0000-0003-1368-2453
Cardiovascular Institute of the South · USPrinceton University · US

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3M
Selective mTORC1 inhibition to prevent and treat NAFLD and NASHR01DK107667 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ARANY, ZOLTAN P · 2016 to 2025
$5.0M
PGC-1 Coactivators in Muscle Angiogenesis IschemiaR01HL094499 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ARANY, ZOLTAN P · 2010 to 2018
$3.7M
NHLBI NIH HHS R01 HL094499NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK107667
6 · The paper itself

Abstract

Endothelial metabolism is a key regulator of angiogenesis. Glutamine metabolism in endothelial cells (ECs) has been poorly studied. We used genetic modifications and

Indexed as

Cell MovementCell ProliferationCarbon IsotopesCulture MediaEndothelial CellsGene DeletionGlutaminaseGlutamineHumansHuman Umbilical Vein Endothelial CellsIsotope LabelingCarbon IsotopesCulture MediaGlutaminaseGlutamineendotheliumglutaminemacropinocytosismigration

Identifiers

PMID28659379
PMCPMC5556269
OpenAlexW2730478846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.