Evidence map›Paper›PMID 28659342›Full record

ArticleThe Journal of biological chemistry2017

Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function.

Joel C D Kaufmann, Benjamin S Krause, Christiane Grimm, Eglof Ritter, Peter Hegemann, Franz J Bartl

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Multicolor photoreactions of the red light-activated channelrhodopsin Chrimson.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  6. Sub-millisecond Control of Neuronal Firing by Organic Light-Emitting Diodes.Frontiers in bioengineering and biotechnology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joel C D KaufmannFrom the Institut für medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany,. Electronic address: joel.kaufmann@charite.de.
Benjamin S KrauseInstitut für Biologie, Experimentelle Biophysik.
Christiane GrimmInstitut für Biologie, Experimentelle Biophysik.
Eglof RitterInstitut für Biologie, Experimentelle Biophysik.
Peter HegemannInstitut für Biologie, Experimentelle Biophysik.
Franz J BartlFrom the Institut für medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany,; Institut für Biologie, Biophysikalische Chemie, Humboldt-Universität zu Berlin, Invalidenstrasse 42, 10115 Berlin, Germany. Electronic address: franz.bartl@hu-berlin.de.
Institut für biologische Forschung · DECharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Channelrhodopsins (ChRs) are light-gated ion channels widely used for activating selected cells in large cellular networks. ChR variants with a red-shifted absorption maximum, such as the modified

Indexed as

Models, MolecularAlgal ProteinsAmino Acid SubstitutionCatalytic DomainChlamydomonas reinhardtiiChlorophytaElectrophysiological PhenomenaHEK293 CellsHumansHydrogen BondingLightMolecular Dynamics SimulationMutagenesis, Site-DirectedMutationPlant ProteinsProtein ConformationAlgal ProteinsPlant ProteinsProtein IsoformsRecombinant Fusion ProteinsRecombinant ProteinsRhodopsinchannelrhodopsinelectrophysiologyFourier transform IR (FTIR)gatingion channelphotobiologyphotocycleproton dynamicsproton transferultraviolet-visible spectroscopy (UV-vis spectroscopy)

Identifiers

PMID28659342
PMCPMC5572910
OpenAlexW2726984317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.