Evidence map›Paper›PMID 28659312›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition.

Prashanth J Prabakaran, Amal M Javaid, Adam D Swick, Lauryn R Werner, Kwangok P Nickel, Emmanuel Sampene, Rong Hu, Irene M Ong, Justine Y Bruce, Gregory K Hartig and 4 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Application of nano-radiosensitizers in combination cancer therapy.Bioengineering & translational medicine · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Application of Radiosensitizers in Cancer Radiotherapy.International journal of nanomedicine · 2021
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Prashanth J PrabakaranDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Amal M JavaidDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Adam D SwickDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Lauryn R WernerDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Kwangok P NickelDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Emmanuel SampeneDepartment of Biostatistics, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Rong HuUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Irene M OngDepartment of Biostatistics, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Justine Y BruceUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Gregory K HartigUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Aaron M WielandUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Jude CanonOncology Research, Amgen, Inc., Thousand Oaks, California.
Paul M HarariDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin.
Randall J KimpleDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health Madison, Madison, Wisconsin. rkimple@humonc.wisc.edu.
University of Wisconsin–Madison · USAmgen (United States) · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Project 4: Role of Receptor Tyrosine Kinase AXL in HNSCC Therapy ResistanceP50DE026787 · NIDCR · UNIVERSITY OF WISCONSIN-MADISON · PI YU, MENGGANG · 2016 to 2020
$10.8M
Head and Neck squamous cell carcinoma radiation response modulation by HPVR00CA160639 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, RANDALL J. · 2013 to 2015
$725k
Head and Neck squamous cell carcinoma radiation response modulation by HPVK99CA160639 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, RANDALL J. · 2011 to 2012
$298k
NCI NIH HHS K99 CA160639NCI NIH HHS P30 CA014520NCI NIH HHS R00 CA160639NIDCR NIH HHS P50 DE026787
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntineoplastic AgentsCarcinoma, Adenoid CysticDisease Models, AnimalFemaleHumansImmunohistochemistryMicePhosphorylationProto-Oncogene Proteins c-mdm2Radiation-Sensitizing AgentsRadiotherapyRadiotherapy DosageSignal TransductionTumor Suppressor Protein p53Xenograft Model Antitumor AssaysAntineoplastic AgentsProto-Oncogene Proteins c-mdm2Radiation-Sensitizing AgentsTumor Suppressor Protein p53

Identifiers

PMID28659312
PMCPMC5641244
OpenAlexW2731663112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.