Evidence map›Paper›PMID 28659310›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression.

Victoria K Xie, Zhiwei Li, Yongmin Yan, Zhiliang Jia, Xiangsheng Zuo, Zhenlin Ju, Jing Wang, Jiawei Du, Dacheng Xie, Keping Xie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Review
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  8. Review
  9. KLF4 is an epigenetically modulated, context-dependent tumor suppressor.Frontiers in cell and developmental biology · 2024
    Review
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  11. Review
  12. Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Victoria K XieDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Zhiwei LiDepartment Gastroenterology Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Yongmin YanDepartment Gastroenterology Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Zhiliang JiaDepartment Gastroenterology Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Xiangsheng ZuoDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Zhenlin JuDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jing WangDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jiawei DuDepartment of Oncology, Shanghai Tongji University East Hospital, Shanghai, P.R. China.
Dacheng XieDepartment of Oncology, Shanghai Tongji University East Hospital, Shanghai, P.R. China.
Keping XieDepartment Gastroenterology Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas. dwei@mdanderson.org kepxie@mdanderson.org.
Daoyan WeiDepartment Gastroenterology Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas. dwei@mdanderson.org kepxie@mdanderson.org.

Funding

Clinical Significance of Pancreatic Cancer Differentiation and DedifferentiationR01CA195651 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WANG, HUAMIN · 2015 to 2021
$1.8M
Integrated Signaling in Pancreatic Cancer ProgressionR01CA198090 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRESALIER, ROBERT S · 2016 to 2021
$1.8M
Molecular Mediators of Pancreatic Cancer Invasion and ProgressionR01CA172233 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRESALIER, ROBERT S · 2013 to 2017
$1.7M
Functional Validation of Pancreatic Cancer Progression BiomarkerR01CA152309 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI XIE, KEPING · 2010 to 2014
$1.6M
KLF4 Genetic and Epigenetic Changes in Human Pancreatic CancerR01CA129956 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI XIE, KEPING · 2008 to 2012
$1.3M
Genetic Approaches to Pancreatic Cancer ProgressionR01CA148954 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI XIE, KEPING · 2010 to 2014
$1.3M
Genetic alterations of KLF4 in human pancreatic cancerR03CA124523 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, DAOYAN · 2006 to 2007
$136k
NCI NIH HHS R01 CA129956NCI NIH HHS R01 CA148954NCI NIH HHS R01 CA152309NCI NIH HHS R01 CA172233NCI NIH HHS R01 CA195651NCI NIH HHS R01 CA198090NCI NIH HHS R03 CA124523
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, NeoplasticGene SilencingAnimalsCell DedifferentiationCell Line, TumorDisease Models, AnimalDNA (Cytosine-5-)-Methyltransferase 1Epigenesis, GeneticFemaleGene ExpressionGenes, ReporterHeterograftsHumansIndolesKruppel-Like Factor 4Kruppel-Like Transcription Factors3,3'-diindolylmethaneDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanIndolesKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsMicroRNAsMIRN152 microRNA, human

Identifiers

PMID28659310
PMCPMC5600846

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.