Evidence map›Paper›PMID 28659285›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

Upregulation of circulating myomiR following short-term energy restriction is inversely associated with whole body protein synthesis.

Lee M Margolis, Donato A Rivas, Stefan M Pasiakos, James P McClung, Lisa Ceglia, Roger A Fielding

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Observational
  5. Circulating miRNAs are associated with successful bone regeneration.Frontiers in bioengineering and biotechnology · 2025
    Article
  6. Small non-coding RNA profiling in patients with gastrointestinal cancer.Journal of cachexia, sarcopenia and muscle · 2023
    Article
  7. Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Nutrition and microRNAs: Novel Insights to Fight Sarcopenia.Antioxidants (Basel, Switzerland) · 2020
    Review
  10. Review
  11. Macronutrient modulation of mRNA and microRNA function in animals: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020
    Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lee M MargolisNutrition, Exercise, Physiology, and Sarcopenia Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Donato A RivasNutrition, Exercise, Physiology, and Sarcopenia Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.ORCID http://orcid.org/0000-0002-4500-6233
Stefan M PasiakosMilitary Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts.
James P McClungMilitary Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts.
Lisa CegliaBone Metabolism Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts; and.
Roger A FieldingNutrition, Exercise, Physiology, and Sarcopenia Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts; Roger.Fielding@Tufts.edu.
Tufts University · USU.S. Army Research Institute of Environmental Medicine · US

Funding

Role of MicroRNAs on Age and Contraction-induced Skeletal Muscle GrowthK01AG047247 · NIA · TUFTS UNIVERSITY BOSTON · PI RIVAS, DONATO A · 2015 to 2019
$488k
NIA NIH HHS K01 AG047247
6 · The paper itself

Abstract

The objective of the present investigation was to determine whether energy restriction (ER) influences expression of skeletal muscle-specific microRNA (miRNA) in circulation (c-myomiR) and whether changes in c-myomiR are associated with rates of whole body protein synthesis. Sixteen older (64 ± 2 yr) overweight (28.5 ± 1.2 kg/m

Indexed as

Caloric RestrictionMicroRNAsUp-RegulationEatingFeedback, PhysiologicalFemaleHumansMiddle AgedMuscle, SkeletalProtein BiosynthesisProteomeMicroRNAsProteomeenergy deficitmicroRNAweight losswhole body protein turnover

Identifiers

PMID28659285
PMCPMC5625273
OpenAlexW2731176431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.