ArticleJournal of biomedical science2017
Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever - a pilot study.
Article in Journal of biomedical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Factors Associated with the Prevalence of Dengue-Leptospirosis Coinfection in Patients Hospitalized for Febrile Syndrome.Tropical medicine and infectious disease · 2026Article
- Cleavage of cell junction proteins as a host invasion strategy in leptospirosis.Applied microbiology and biotechnology · 2024Review
- Dengue and leptospirosis coinfection: a case series.Journal of medical case reports · 2024Article
- Distribution, frequency and clinical presentation of leptospirosis and coinfections: a systematic review protocol.BMJ open · 2022Article
- The diagnosis of leptospirosis complicated by pulmonary tuberculosis complemented by metagenomic next-generation sequencing: A case report.Frontiers in cellular and infection microbiology · 2022Article
- Leptospirosis and Coinfection: Should We Be Concerned?International journal of environmental research and public health · 2021Review
- Leptospirosis in febrile patients with suspected diagnosis of dengue fever.BMC research notes · 2021Article
- Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia.PLoS neglected tropical diseases · 2020Article
- Usefulness of C-Reactive Protein in Differentiating Acute Leptospirosis and Dengue Fever in French Guiana.Open forum infectious diseases · 2019Article
- An outbreak of leptospirosis with predominant cardiac involvement: a case series.BMC infectious diseases · 2019Article
- Fatal Dengue, Chikungunya and Leptospirosis: The Importance of Assessing Co-infections in Febrile Patients in Tropical Areas.Tropical medicine and infectious disease · 2018Article
- Prevalence of dengue and leptospirosis co-infection in a tertiary care hospital in south India.Iranian journal of microbiology · 2018Article
- Leptospirosis among Returned Travelers: A GeoSentinel Site Survey and Multicenter Analysis-1997-2016.The American journal of tropical medicine and hygiene · 2018Article
- Rapid, actionable diagnosis of urban epidemic leptospirosis using a pathogenic Leptospira lipL32-based real-time PCR assay.PLoS neglected tropical diseases · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection.
methodTwo hundred sixty eight serum specimens collected from patients that were diagnosed for dengue fever were confirmed for dengue virus serotyping by real-time polymerase chain reaction. Clinical, laboratory and demographic data were extracted from the hospital database to identify patients with confirmed leptospirosis infection among the dengue patients. Thus, frequency of co-infection was calculated and association of the dataset with dengue-leptospirosis co-infection was statistically determined.
resultsThe frequency of dengue co-infection with leptospirosis was 4.1%. Male has higher preponderance of developing the co-infection and end result of shock as clinical symptom is more likely present among co-infected cases. It is also noteworthy that, DENV 1 is the common dengue serotype among all cases identified as dengue-leptospirosis co-infection in this study.
conclusionThe increasing incidence of leptospirosis among dengue infected patients has posed the need to precisely identify the presence of co-infection for the betterment of treatment without mistakenly ruling out either one of them. Thus, anticipating the possible clinical symptoms and laboratory results of dengue-leptospirosis co-infection is essential.
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