Evidence map›Paper›PMID 28659168›Full record

ArticleBMC systems biology2017

Gene expression profiles and signaling mechanisms in α

Anna Huhtinen, Vesa Hongisto, Asta Laiho, Eliisa Löyttyniemi, Dirk Pijnenburg, Mika Scheinin

Open access · diamondAbstract read
In one paragraph

Article in BMC systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Role of G-protein coupled receptors in cardiovascular diseases.Frontiers in cardiovascular medicine · 2023
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. [Dexmedetomidine alleviates cognitive dysfunction induced by tibial fracture in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anna HuhtinenDepartment of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland. anna.huhtinen@utu.fi.ORCID http://orcid.org/0000-0003-0080-2153
Vesa HongistoToxicology Division, Misvik Biology Oy, Turku, Finland.
Asta LaihoTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, Department of Clinical Medicine, University of Turku, Turku, Finland.
Dirk PijnenburgPamGene International BV, Wolvenhoek 10, 5211HH, s'Hertogenbosch, The Netherlands.
Mika ScheininDepartment of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland.
University of Turku · FIÅbo Akademi University · FIPamGene (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundα

resultsThe cellular mechanisms and signaling pathways of α

conclusionsα

Indexed as

Gene Expression ProfilingSignal TransductionAnimalsCell LineCell ProliferationDexmedetomidineDrug Evaluation, PreclinicalKineticsMuscle, Smooth, VascularOligonucleotide Array Sequence AnalysisPhosphoric Monoester HydrolasesProtein Kinase InhibitorsReceptors, Adrenergic, alpha-2DexmedetomidinePhosphoric Monoester HydrolasesProtein Kinase InhibitorsReceptors, Adrenergic, alpha-2A7r5 cell lineAlpha2-adrenoceptorDNA microarrayFunctional analysisKinase activity profilingKinase inhibitorPathway analysisVascular smooth muscle cell

Identifiers

PMID28659168
PMCPMC5490158
OpenAlexW2727082118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.