Evidence map›Paper›PMID 28659161›Full record

Trial reportBMC geriatrics2017

Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment.

Elizabeth Dao, John R Best, Ging-Yuek Robin Hsiung, Vesna Sossi, Claudia Jacova, Roger Tam, Teresa Liu-Ambrose

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01027858 (Role of Exercise on Cognition and Function in Seniors With Vascular Cognitive Impairment), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01027858 nacompletednot on this map

Role of Exercise on Cognition and Function in Seniors With Vascular Cognitive Impairment: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2009 to 2015Enrolled71ConditionsVascular Cognitive ImpairmentArmsAerobic-based exercise training, CON (control, usual care)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements - a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Elizabeth DaoDepartment of Physical Therapy, University of British Columbia, 212 - 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
John R BestDepartment of Physical Therapy, University of British Columbia, 212 - 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Ging-Yuek Robin HsiungDjavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6S 0A9, Canada.
Vesna SossiDepartment of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC, V6T 1Z1, Canada.
Claudia JacovaSchool of Graduate Psychology, Pacific University, 190 SE 8th Avenue, Hillsboro, OR, 97123, USA.
Roger TamMS/MRI Research Group, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6S 0A9, Canada.
Teresa Liu-AmbroseDepartment of Physical Therapy, University of British Columbia, 212 - 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. teresa.ambrose@ubc.ca.
University of British Columbia · CAPacific University Oregon · USUniversity of British Columbia Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI).

methodsThis is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858). The subset of individuals completed an

resultsHigher PIB retention was significantly associated with greater decrements in set shifting (Trail Making Test, adjusted R

conclusionsSymptoms associated with SIVCI may be amplified by secondary Aβ pathology.

trial registrationClinicalTrials.gov, NCT01027858 , December 7, 2009.

Indexed as

Accidental FallsAgedAged, 80 and overBrainCognitionCognitive DysfunctionDementia, VascularExerciseFemaleHumansMaleMiddle AgedPlaque, AmyloidRisk FactorsTrail Making TestAlzheimer’s diseaseAmyloidCognitive impairmentExecutive functionsFalls riskVascular cognitive impairment

Identifiers

PMID28659161
PMCPMC5490153
OpenAlexW2732470993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.