Evidence map›Paper›PMID 28659136›Full record

Trial reportBMC public health2017

Risk of chronic liver disease in post-menopausal women due to body mass index, alcohol and their interaction: a prospective nested cohort study within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Paul M Trembling, Sophia Apostolidou, Aleksandra Gentry-Maharaj, Julie Parkes, Andy Ryan, Sudeep Tanwar, Matthew Burnell, Ian Jacobs, Usha Menon, William M Rosenberg

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Paul M TremblingInstitute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK. p.trembling@ucl.ac.uk.
Sophia ApostolidouGynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Aleksandra Gentry-MaharajGynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Julie ParkesPublic Health Sciences and Medical Statistics, Faculty of Medicine, University of Southampton, Southampton, UK.
Andy RyanGynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Sudeep TanwarInstitute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.
Matthew BurnellGynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Ian JacobsGynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Usha MenonGynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
William M RosenbergInstitute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, UK.
University College London · GBRoland Hill (United Kingdom) · GBUniversity College Hospital · GBThe Royal Free Hospital · GBUniversity of Southampton · GBUNSW Sydney · AU

Funding

Medical Research Council G0801228Medical Research Council G9901012
6 · The paper itself

Abstract

backgroundWe investigated the risk of chronic liver disease (CLD) due to alcohol consumption and body mass index (BMI) and the effects of their interaction in a prospective cohort study of women recruited to the UKCTOCS trial.

methods95,126 post-menopausal women without documented CLD were stratified into 12 groups defined by combinations of BMI (normal, overweight, obese) and alcohol consumption (none, <1-15, 16-20 and ≥21 units/week), and followed for an average of 5.1 years. Hazard ratios (HR) were calculated for incident liver-related events (LRE).

resultsFirst LREs were reported in 325 (0.34%) participants. Compared to women with normal BMI, HR = 1.44 (95% CI; 1.10-1.87) in the overweight group and HR = 2.25 (95% CI; 1.70-2.97) in the obese group, adjusted for alcohol and potential confounders. Compared to those abstinent from alcohol, HR = 0.70 (95% CI; 0.55-0.88) for <1-15 units/week, 0.93 (95% CI; 0.50-1.73) for 16-20 units/week and 1.82 (95% CI; 0.97-3.39) for ≥21 units/week adjusted for BMI and potential confounders. Compared to women with normal BMI drinking no alcohol, HR for LRE in obese women consuming ≥21 units/week was 2.86 (95% CI; 0.67-12.42), 1.58 (95% CI; 0.96-2.61) for obese women drinking <1-15 units/week and 1.93 (95% CI; 0.66-5.62) in those with normal BMI consuming ≥21 units/week after adjustment for potential confounders. We found no significant interaction between BMI and alcohol.

conclusionHigh BMI and alcohol consumption and abstinence are risk factors for CLD in post-menopausal women. However, BMI and alcohol do not demonstrate significant interaction in this group.

trial registrationUKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978 . Registered 06/04/2000.

Indexed as

Body Mass IndexAgedAlcohol DrinkingChronic DiseaseEthanolFemaleHumansLiver DiseasesMiddle AgedObesityOvarian NeoplasmsOverweightPostmenopauseProportional Hazards ModelsProspective StudiesRisk FactorsEthanolAlcoholBody mass indexChronic liver diseaseCirrhosisObesity

Identifiers

PMID28659136
PMCPMC5490218
OpenAlexW2726681431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.