Evidence map›Paper›PMID 28658926›Full record

ReviewJournal of clinical and diagnostic research : JCDR2017

Role of Vitamin E and Vitamin A in Oral Mucositis Induced by Cancer Chemo/Radiotherapy- A Meta-analysis.

Nallan Csk Chaitanya, Arvind Muthukrishnan, Dara Balaji Gandhi Babu, Chinta Sanjeeva Kumari, Madishetty Adi Lakshmi, Gayathri Palat, Khwaja Shoeb Alam

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nallan Csk ChaitanyaPhd Research Scholar, Department of Oral Medicine and Radiology, Saveetha University, Chennai, Tamil Nadu, India.
Arvind MuthukrishnanProfessor and Guide, Department of Oral Medicine And Radiology, Saveetha University, Saveetha Dental College, Chennai, Tamil Nadu, India.
Dara Balaji Gandhi BabuProfessor and Head, Department of Oral Medicine And Radiology, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India.
Chinta Sanjeeva KumariProfessor, Department of Radiation Oncology, MNJ Institute of Oncology and Regional Cancer Center, Hyderabad, Telangana, India.
Madishetty Adi LakshmiAssistant Professor, Department of Radiation Oncology, MNJ Institute of Oncology and Regional Cancer Center, Hyderabad, Telangana, India.
Gayathri PalatConsultant, Department of Pain and Palliative Care, MNJ Institute of Oncology and Regional Cancer Center, Hyderabad, Telangana, India.
Khwaja Shoeb AlamJunior Resident, Department of Oral Medicine and Radiology, Panineeya Institute of Dental Sciences, Hyderabad, Telangana, India.
Saveetha University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOral mucositis is known to hamper the quality of life in patients treated for oral cancer. Many pharmacological agents have been tried and tested in its management, especially vitamin supplements including A, E and their combinations.

aimA Meta-analysis was carried out to evaluate the efficacy of vitamins individually used for prevention or treatment of oral mucositis separately for chemotherapy, concurrent chemo radiotherapy, radiotherapy and Haematopoietic Stem Cell Transplantation (HSCT) individuals. MATERIALS AND

methodsThe literature study was done using PUBMED, MEDLINE, EBSCO, GOOGLE SCHOLAR and COCHRANE data bases with keywords vitamin A, vitamin E, vitamin B, vitamin C, Oral mucositis, Chemotherapy, Radiotherapy, Concurrent chemo radiotherapy and Haematopoietic stem cell transplantation individually, from the year 1980 to 2016. Only randomized controlled trials were included. The data was extracted, tabulated and was subjected to statistical analysis with CI of 95%.

resultsAmong 201 subjects the analysis clearly demonstrated a male predominance to females in studies where male to female ratio was given. Out of 8 studies, 2 were studies in children and remaining 6 studies concentrated on adult population. WHO and NCI-CTC criteria were followed except for one study which used customised assessment. A meta-analysis was performed regarding usage of topical medication of Vitamin E group in all three cancer treatment modalities, which showed significant reduction in oral mucositis (p < 0.001). There was reduced oral mucositis in a small group of patients with Vitamin A when compared to controls. No information on the agent used for chemotherapy, the dose of radiotherapy and the type of tumours in 4 studies.

conclusionTopical Vitamin E had performed better on oral mucositis than Vitamin E systemic administration. Though the efficacy of topical treatment with Vitamin A showed reduction in oral mucositis, it was evaluated in a very small sample which cannot be attributed to a larger sitting.

Indexed as

Epithelial proliferationHaematopoietic stem cell transplantationLevels of evidence

Identifiers

PMID28658926
PMCPMC5483828
OpenAlexW2625116763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.