ArticleJournal of clinical and diagnostic research : JCDR2017
Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis.
Article in Journal of clinical and diagnostic research : JCDR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Surgical and mucogingival management of an oral pyogenic granuloma associated with fixed orthodontic treatment in an adolescent patient: a case report.Journal of surgical case reports · 2026Article
- The Expression of HIF-1α and VEGF in Radicular Cysts and Periapical Granulomas.European journal of dentistry · 2025Article
- Oral Pyogenic Granuloma: A Narrative Review.International journal of molecular sciences · 2023Review
- Article
- Molecular pathogenicity of 1-nonadecene and L-lactic acid, unique metabolites in radicular cysts and periapical granulomas.Scientific reports · 2023Article
- A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence.BMC oral health · 2023Article
- The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered.European endodontic journal · 2023Review
- Pyogenic Granuloma of the Retina: A Case Series.Ocular oncology and pathology · 2019Article
- Quantification of inflammatory, angiogenic, and fibrous components of reactive oral lesions with an insight into the pathogenesis.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionAngiogenesis is vital in the aetiology and pathogenesis of a number of pathological processes that include solid reactive lesions like pyogenic granuloma and chronic inflammatory disorders like periapical granuloma. Vascular Endothelial Growth Factor (VEGF) is a potent proangiogenic cytokine secreted by many cell types which present several pivotal functions in physiologic and pathologic angiogenesis.
aimThe aim of the present study was to evaluate and compare the expression of VEGF in oral Pyogenic Granuloma (PG) and Periapical Granuloma (PAG) and also to correlate with the inflammatory cell infiltrate. MATERIALS AND
methodsParaffin embedded tissue blocks of histologically diagnosed cases of PG and PAG, 20 of each were retrieved from the archives. The cases were selected randomly to evaluate the expression of VEGF marker and to assess the Mean Vascular Count (MVC) index and inflammation by Morphological Index (MI). The results were analysed using Unpaired t-test, Mann-Whitney U test and spearman correlation coefficient-test.
resultsThe PG showed higher expression of VEGF when compared to PAG with no significant difference in inflammation. PG showed positive correlation and PAG showed negative correlation between inflammation and VEGF expression.
conclusionHistologically similar PG and PAG are different not only by their clinical presentation but also by their mechanisms of formation and molecular sketch. Thereby raised expression of VEGF marker was established in PG emphasizing the fact that all histologically similar lesions need not have similar clinical course and molecular depiction.
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