ArticleCell reports2017
Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.
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In one paragraph
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
What it found
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Who cites it
46 citing papers in PubMed, 69 citations in OpenAlex.
- A potent alternative cysteine production pathway allows reductase independence.Nature chemical biology · 2026Article
- Cystine C-S bond cleavage fuels cysteine production under disulfide reductase deficiency.Nature chemical biology · 2026Article
- Epigenetic Mechanisms Governing Nrf2 Expression and Its Role in Ferroptosis.Biomedicines · 2025Review
- Androgen-induced ferroptosis regulates seasonal testicular regression: insights into adaptive mechanisms of seasonal breeding.BMC genomics · 2025Article
- Unveiling the Role of Selenium in Child Development: Impacts on Growth, Neurodevelopment and Immunity.Journal of clinical medicine · 2025Review
- Nrf2 and Ferroptosis: Exploring Translational Avenues for Therapeutic Approaches to Neurological Diseases.Current drug targets · 2025Review
- TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.The EMBO journal · 2024Article
- Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models.Biology · 2024Review
- Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.Advances in cancer research · 2024Review
- Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases.Frontiers in cellular neuroscience · 2024Review
- Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal SecMolecules (Basel, Switzerland) · 2023Article
- Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress.Cell biochemistry and biophysics · 2023Article
- Glutathione-Related Enzymes and Proteins: A Review.Molecules (Basel, Switzerland) · 2023Review
- Ce doped polyaniline nanoparticles for absorption and photoacoustic imaging response to GSHBioactive materials · 2022Article
- Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor.Experimental hematology & oncology · 2022Article
- Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death.Cancers · 2022Article
- Thioredoxin Reductase 1 Modulates Pigmentation and Photobiology of Murine Melanocytes in vivo.The Journal of investigative dermatology · 2022Article
- Emerging Evidence of the Significance of Thioredoxin-1 in Hematopoietic Stem Cell Aging.Antioxidants (Basel, Switzerland) · 2022Review
- The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.PloS one · 2022Article
- The Critical Role of Ferroptosis in Hepatocellular Carcinoma.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Justin R PriggeMicrobiology & Immunology, Montana State University, Bozeman, MT 59718, USA.
Lucia CoppoDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Sebastin S MartinDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Fernando OgataDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Colin G MillerMicrobiology & Immunology, Montana State University, Bozeman, MT 59718, USA.
Michael D BruschweinMicrobiology & Immunology, Montana State University, Bozeman, MT 59718, USA.
David J OrlickyDepartment of Pathology, University of Colorado Anschutz Medical Center, Denver, CO 80045, USA.
Colin T ShearnDepartment of Pharmaceutical Sciences, University of Colorado Anschutz Medical Center, Denver, CO 80045, USA.
Jean A KundertMicrobiology & Immunology, Montana State University, Bozeman, MT 59718, USA.
Julia LytchierDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Alix E HerrMicrobiology & Immunology, Montana State University, Bozeman, MT 59718, USA.
Åse MattssonDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Matthew P TaylorMicrobiology & Immunology, Montana State University, Bozeman, MT 59718, USA.
Tomas N GustafssonDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Clinical Microbiology, Clinical Bacteriology, Sunderby Research Unit, Umeå University, 901 85 Umeå, Sweden.
Elias S J ArnérDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Arne HolmgrenDivision of Biochemistry, Medical Biochemistry & Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Edward E SchmidtMicrobiology & Immunology, Montana State University, Bozeman, MT 59718, USA. Electronic address: eschmidt@montana.edu.
Karolinska Institutet · SEMontana State University · USUniversity of Colorado Anschutz Medical Campus · USUmeå University · SE
Funding
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6MUniversity of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5MUAB Diabetes Research and Training CenterP60DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GARVEY, W TIMOTHY · 2008 to 2012
$8.4MPilot Grants ProgramP30GM110732 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI QUINN, MARK T · 2014 to 2018
$5.4MThe Maternal/Fetal InteractionR01AI055739 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI SCHMIDT, EDWARD E · 2005 to 2009
$1.7MImpact of hepatocyte lineage life history dynamics on liver homeostasis in the agR01AG040020 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI GEDEON, TOMAS, SCHMIDT, EDWARD E · 2011 to 2015
$1.5MRedox regulation in the hepatostatR21AG055022 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI ARNER, ELIAS S.J., NAGY, PETER · 2016 to 2017
$382kNIAID NIH HHS R01 AI055739NIA NIH HHS R01 AG040020NIA NIH HHS R21 AG055022NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P60 DK079626NIGMS NIH HHS P30 GM110732
Abstract
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP
Indexed as
AnimalsCell ProliferationGlutathione ReductaseHepatocytesHumansMaleMiceThioredoxin Reductase 1ThioredoxinsGlutathione ReductaseThioredoxin Reductase 1Thioredoxinscancerglutathionelivermethionine cyclemouse modelproliferationredoxribonucleotide reductasethioredoxintranssulfuration
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.