ArticleCell reports2017
Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Experience-dependent critical period for synaptic plasticity in the rat olfactory amygdala.Frontiers in synaptic neuroscience · 2026Review
- Transient synaptic refinement and glial adaptations after whisker denervation in adult mice.Frontiers in cellular neuroscience · 2026Article
- Article
- Reactivated thalamocortical plasticity alters neural activity in sensory-motor cortex during post-critical period.Progress in neurobiology · 2025Article
- Behavioral adaptations after unilateral whisker denervation.Behavioural brain research · 2025Article
- Transcranial Low-Intensity Focused Ultrasound Stimulation of the Visual Thalamus Produces Long-Term Depression of Thalamocortical Synapses in the Adult Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The Shaping of AMPA Receptor Surface Distribution by Neuronal Activity.Frontiers in synaptic neuroscience · 2022Review
- Silent Synapses in Cocaine-Associated Memory and Beyond.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- (-)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression.Scientific reports · 2021Article
- Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical Takeover.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Plasticity in Adult Mouse Visual Cortex Following Optic Nerve Injury.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Mechanisms of Homeostatic Synaptic PlasticityFrontiers in cellular neuroscience · 2019Review
- Evidence of Hyperacusis in Adult Rats Following Non-traumatic Sound Exposure.Frontiers in systems neuroscience · 2019Article
- Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice.Cell reports · 2018Article
- The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity.International journal of molecular sciences · 2017Review
- Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice.Molecular painArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
Abstract
Recent work has shown that thalamocortical (TC) inputs can be plastic after the developmental critical period has closed, but the mechanism that enables re-establishment of plasticity is unclear. Here, we find that long-term potentiation (LTP) at TC inputs is transiently restored in spared barrel cortex following either a unilateral infra-orbital nerve (ION) lesion, unilateral whisker trimming, or unilateral ablation of the rodent barrel cortex. Restoration of LTP is associated with increased potency at TC input and reactivates anatomical map plasticity induced by whisker follicle ablation. The reactivation of TC LTP is accompanied by reappearance of silent synapses. Both LTP and silent synapse formation are preceded by transient re-expression of synaptic GluN2B-containing N-methyl-D-aspartate (NMDA) receptors, which are required for the reappearance of TC plasticity. These results clearly demonstrate that peripheral sensory deprivation reactivates synaptic plasticity in the mature layer 4 barrel cortex with features similar to the developmental critical period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.