Evidence map›Paper›PMID 28658558›Full record

ReviewImmunological reviews2017

The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines.

Hongwei Han, Florence Roan, Steven F Ziegler

Abstract readReview
In one paragraph

Review in Immunological reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
31.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 273 citations in OpenAlex.

  1. Trial
  2. Article
  3. Effects of pre- and postnatal probiotic and ω-3 fatty acid supplementation on cytokine and chemokine responses to allergens and TLR ligands during infancy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Squaric Acid Dibutylester Promotes Innate Immune-Driven Hair Growth with CD206JID innovations : skin science from molecules to population health · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hongwei HanImmunology Program, Benaroya Research Institute, Seattle, WA, USA.
Florence RoanImmunology Program, Benaroya Research Institute, Seattle, WA, USA.
Steven F ZieglerImmunology Program, Benaroya Research Institute, Seattle, WA, USA.ORCID 0000-0002-9043-9273
Benaroya Research InstituteUniversity of Washington · US

Funding

Thymic Stromal Lymphopoietin (TSLP) and Lung Inflammation and ImmP01HL098067 · NHLBI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI FREVERT, CHARLES WAYNE · 2010 to 2014
$13.5M
Regulation of the Innate Immune Response by the Epithelium in AsthmaU19AI125378 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J · 2016 to 2020
$9.2M
TSLP and the Pathophysiology of AsthmaR01AI068731 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2006 to 2016
$4.5M
IL-33 and food allergyR01AI124220 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2016 to 2020
$3.0M
NHLBI NIH HHS P01 HL098067NIAID NIH HHS R01 AI068731NIAID NIH HHS R01 AI124220NIAID NIH HHS U19 AI125378
6 · The paper itself

Abstract

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy. This review focuses on current concepts of the role of skin barrier defects and epithelial cell-derived cytokines in the initiation and maintenance of allergic inflammation and the atopic march.

Indexed as

AllergensAnimalsCytokinesDermatitis, AtopicEnvironmentEpithelial CellsGenetic Predisposition to DiseaseHumansImmune ToleranceImmunizationImmunotherapySkinAllergensCytokinesallergicatopicepithelialIL-33inflammationTSLP

Identifiers

PMID28658558
PMCPMC5492959
OpenAlexW2728647913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.