ArticlePloS one2017
Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.Nature neuroscience · 2026Article
- A comprehensive study of c-Kit-expressing amacrine cells in the mammalian retina.Scientific reports · 2025Article
- Article
- A deep-learning strategy to identify cell types across species from high-density extracellular recordings.bioRxiv : the preprint server for biology · 2024Article
- Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells.eLife · 2024Article
- An enhancer-AAV approach selectively targeting dentate granule cells of the mouse hippocampus.Cell reports methods · 2024Article
- Revisiting the development of cerebellar inhibitory interneurons in the light of single-cell genetic analyses.Histochemistry and cell biology · 2024Review
- Social memory deficit caused by dysregulation of the cerebellar vermis.Nature communications · 2023Article
- Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1.Cells · 2023Article
- Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition.Genome medicine · 2023Article
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Morphological pseudotime ordering and fate mapping reveal diversification of cerebellar inhibitory interneurons.Nature communications · 2022Article
- Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling.Nature neuroscience · 2020Article
- Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex.Synapse (New York, N.Y.) · 2019Article
- Article
- Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum.The Journal of physiology · 2019Article
- Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum.Neuron · 2018Article
- Inhibition gates supralinear CaeLife · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of the cerebellar cortex, therefore, any cerebellar involvement in motor activity must be driven by changes in PC firing rates. Several different cell types influence PC activity including excitatory input from parallel fibers and inhibition from molecular layer interneurons (MLIs). Similar to PCs, MLI activity is driven by parallel fibers, therefore, MLIs provide feed-forward inhibition onto PCs. To aid in the experimental assessment of how molecular layer inhibition contributes to cerebellar function and motor behavior, we characterized a new knock-in mouse line with Cre recombinase expression under control of endogenous c-kit transcriptional machinery. Using these engineered c-Kit mice, we were able to obtain high levels of conditional MLI transduction in adult mice using Cre-dependent viral vectors without any PC or granule cell labeling. We then used the mouse line to target MLIs for activity perturbation in vitro using opto- and chemogenetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.