ArticlePloS one2017
Heritability of hoarding symptoms across adolescence and young adulthood: A longitudinal twin study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals.Translational psychiatry · 2022Pooled it
- Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021Pooled it
- Estimating the Heritability of Hoarding Symptoms: Insights from a Classical Twin Study "New Insights on the Nature of Clutter".Iranian journal of psychiatry · 2024Article
- Hoarding Disorder: Development in Conceptualization, Intervention, and Evaluation.Focus (American Psychiatric Publishing) · 2021Article
- The developmental origins of hoarding disorder in adolescence: a longitudinal clinical interview study following an epidemiological survey.European child & adolescent psychiatry · 2021Article
- Recent Advances in Research on Hoarding.Current psychiatry reports · 2019Review
- Relevance of hoarding behavior and the traits of developmental disorders among university students: a self-reported assessment study.BioPsychoSocial medicine · 2019Article
- Pharmacotherapy for Hoarding Disorder: How did the Picture Change since its Excision from OCD?Current neuropharmacology · 2019Review
- Prevalence and heritability of body dysmorphic symptoms in adolescents and young adults: a population-based nationwide twin study.Psychological medicine · 2018Article
- Psychometric Evaluation of a Revised Scoring Approach for the Children's Saving Inventory in a Canadian Sample of Youth With Obsessive-Compulsive Disorder.Child psychiatry and human development · 2018Article
- Predictors of treatment outcome and attrition in adults with hoarding disorder.Journal of obsessive-compulsive and related disorders · 2018Article
- Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
backgroundTwin studies of hoarding symptoms indicate low to moderate heritability during adolescence and considerably higher heritability in older samples, suggesting dynamic developmental etiological effects. The aim of the current study was to estimate the relative contribution of additive genetic and environmental effects to hoarding symptoms during adolescence and young adulthood and to estimate the sources of stability and change of hoarding symptoms during adolescence.
methodsUnivariate model-fitting was conducted in three cohorts of twins aged 15 (n = 7,905), 18 (n = 2,495) and 20-28 (n = 6,218). Longitudinal analyses were conducted in a subsample of twins for which data on hoarding symptoms was available at both age 15 and 18 (n = 1,701).
resultsHeritability estimates for hoarding symptoms at ages 15, 18 and 20-28 were 41% (95% confidence interval [CI]: 36-45%), 31% (95% CI: 22-39%) and 29% (95% CI: 24-34%) respectively. Quantitative sex-differences emerged in twins aged 15 at which point the heritability in boys was 33% (95% CI: 22-41%) and 17% (95% CI: 0-36%) in girls. Shared environmental effects played a negligible role across all samples with the exception of girls aged 15 where they accounted for a significant proportion of the variance (22%; 95% CI 6-36%). The longitudinal bivariate analyses revealed a significant phenotypic correlation of hoarding symptoms between ages 15 and 18 (0.40; 95% CI: 0.36-0.44) and a strong but imperfect genetic correlation (0.75; 95% CI: 0.57-0.94). The bivariate heritability was estimated to 65% (95% CI: 50-79%).
conclusionsHoarding symptoms are heritable from adolescence throughout young adulthood, although heritability appears to slightly decrease over time. Shared environmental effects contribute to hoarding symptoms only in girls at age 15. The stability of hoarding symptoms between ages 15 and 18 is largely explained by genetic factors, while non-shared environmental factors primarily have a time-specific effect. The findings indicate that dynamic developmental etiological effects may be operating across the life span.
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