ArticlePloS one2017
Genetic basis of calcifying cystic odontogenic tumors.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.Head and neck pathology · 2022Pooled it
- Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review.Head and neck pathology · 2021Pooled it
- Genetic Profile of Adenomatoid Odontogenic Tumor and Ameloblastoma. A Systematic Review.Frontiers in oral health · 2021Pooled it
- Primordial odontogenic tumor: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Immunohistochemical Expression of CK13 and Molecular Analysis of KRT13 and APC in Odontogenic Ghost Cell Lesions, Adenoid Ameloblastoma, and Conventional Ameloblastoma.Head and neck pathology · 2026Article
- Biological Characterization of Odontogenic Ghost Cell Lesions: A Clinicopathological, Immunohistochemical and Molecular Study of a Unicentric Series of 69 Cases.Head and neck pathology · 2025Article
- Dentinogenic ghost cell tumor in a pediatric patient: A case report and literature review.Medicine · 2025Review
- Long-Term Outcomes of Surgical Decompression in Treating Calcifying Odontogenic Cyst Associated With Compound Odontoma: A 9-Year Follow-Up Case Report and Literature Review.Case reports in dentistry · 2025Article
- Title of the article: diagnostic markers for odontogenic tumors: an insight: a review.Discover oncology · 2024Review
- NovelJournal of dental sciences · 2024Article
- A Calcifying Odontogenic Cyst With Compound Odontoma in the Maxillary Sinus: A Case Report in a Pediatric Patient.Cureus · 2024Article
- Odontogenic Carcinosarcoma: Clinicopathologic and Molecular Features of Three Cases, a Literature Review and Nomenclature Proposal.Head and neck pathology · 2023Review
- [The new WHO classification of jaw tumours].Pathologie (Heidelberg, Germany) · 2023Review
- Calcifying odontogenic cyst combined with odontogenic keratocyst: report of a case and review of the literature.International journal of surgery case reports · 2023Article
- Dentinogenic ghost cell tumor: a case report and review of the literature.Oral and maxillofacial surgery · 2023Review
- Review
- Ghost Cell Odontogenic Carcinoma Arising in a Previous Calcifying Odontogenic Cyst: A Case Report and Review of Literature.Head and neck pathology · 2022Review
- Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis.International journal of oral science · 2022Article
- Useful diagnostic histogenetic features of ectopic odontogenic ghost cell tumours.BMC oral health · 2022Article
- The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition.Turk patoloji dergisi · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcifying cystic odontogenic tumors (CCOTs) are benign cystic tumors that form abnormally keratinized ghost cells. Mutations in CTNNB1, which encodes beta-catenin, have been implicated in the development of these tumors, but a causal relationship has not been definitively established. Thus, mutational hot spots in 50 cancer genes were examined by targeted next-generation sequencing in 11 samples of CCOT. Mutations in CTNNB1, but not in other genes, were observed in 10 of 11 cases. These mutations constitutively activate beta-catenin signaling by abolishing the phosphorylation sites Asp32, Ser33, or Ser37, and are similar to those reported in pilomatrixoma and adamantinomatous craniopharyngioma. In contrast, BRAF or NRAS mutations were observed in 12 and two control samples of ameloblastoma, respectively. In HEK293 cells, overexpression of mutated CTNNB1 also upregulated hair keratin, a marker of ghost cells. Furthermore, ghost cells were present in two cases of ameloblastoma with BRAF and CTNNB1 mutations, indicating that ghost cells form due to mutations in CTNNB1. The data suggest that mutations in CTNNB1 are the major driver mutations of CCOT, and that CCOT is the genetic analog of pilomatrixoma and adamantinomatous craniopharyngioma in odontogenic tissue.
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