ArticlePLoS neglected tropical diseases2017
Leptospira diversity in animals and humans in Tahiti, French Polynesia.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity.PLoS neglected tropical diseases · 2018Pooled it
- Molecular detection of a Leptospira lineage with high similarity to Leptospira kirschneri in human, environmental, and rodent samples from Gilan Province, Iran: an integrated field and laboratory investigation.GMS hygiene and infection control · 2026Article
- Land use shapes riverine nutrient and sediment concentrations on Moorea, French Polynesia.Scientific reports · 2025Article
- Domestic dogs in indigenous Amazonian communities: Key players in Leptospira cycling and transmission?PLoS neglected tropical diseases · 2024Article
- Molecular Epidemiology of PathogenicAnimals : an open access journal from MDPI · 2023Article
- Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing.BMC infectious diseases · 2023Article
- PathogenicMicroorganisms · 2022Article
- Diversity of Leptospira spp. in bats and rodents from Papua New Guinea.Transboundary and emerging diseases · 2022Article
- Fine-scale prevalence and genetic diversity of urban small mammal-borne pathogenic Leptospira in Africa: A spatiotemporal survey within Cotonou, Benin.Zoonoses and public health · 2022Article
- Co-Radiation ofTropical medicine and infectious disease · 2022Article
- Pathogenic Leptospira Species Are Widely Disseminated among Wild Rodents in Urban Areas of Guangzhou, Southern China.Microorganisms · 2022Article
- Article
- Circulating genotypes of Leptospira in French Polynesia : An 9-year molecular epidemiology surveillance follow-up study.PLoS neglected tropical diseases · 2020Article
- High frequency of seropositive and carriers of Leptospira spp. in pigs in the semiarid region of northeastern Brazil.Tropical animal health and production · 2020Article
- Environmental Risk of Leptospirosis in Animals: The Case of The Republic of Sakha (Yakutia), Russian Federation.Pathogens (Basel, Switzerland) · 2020Article
- Leptospira infection in rats: A literature review of global prevalence and distribution.PLoS neglected tropical diseases · 2019Review
- Genetic characteristics of pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015.PLoS neglected tropical diseases · 2019Article
- Leptospirosis in French Polynesia: 11 years of surveillance data, 2007-2017.New microbes and new infections · 2019Article
- Infections in French Polynesia.New microbes and new infections · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeptospirosis is a highly endemic bacterial zoonosis in French Polynesia (FP). Nevertheless, data on the epidemiology of leptospirosis in FP are scarce. We conducted molecular studies on Leptospira isolated from humans and the potential main animal reservoirs in order to identify the most likely sources for human infection. METHODOLOGY/PRINCIPAL
findingsWild rats (n = 113), farm pigs (n = 181) and domestic dogs (n = 4) were screened for Leptospira infection in Tahiti, the most populated island in FP. Positive samples were genotyped and compared to Leptospira isolated from human cases throughout FP (n = 51), using secY, 16S and LipL32 sequencing, and MLST analysis. Leptospira DNA was detected in 20.4% of rats and 26.5% of pigs. We identified two Leptospira species and three sequence types (STs) in animals and humans: Leptospira interrogans ST140 in pigs only and L. interrogans ST17 and Leptospira borgpetersenii ST149 in humans and rats. Overall, L. interrogans was the dominant species and grouped into four clades: one clade including a human case only, two clades including human cases and dogs, and one clade including human cases and rats. All except one pig sample showed a unique L. interrogans (secY) genotype distinct from those isolated from humans, rats and dogs. Moreover, LipL32 sequencing allowed the detection of an additional Leptospira genotype in pigs, clearly distinct from the previous ones. CONCLUSIONS/SIGNIFICANCE: Our data confirm rats as a major potential source for human leptospirosis in FP. By contrast to what was expected, farm pigs did not seem to be a major reservoir for the Leptospira genotypes identified in human patients. Thus, further investigations will be required to determine their significance in leptospirosis transmission in FP.
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