ArticlePsychosomatic medicine
Genetic and Environmental Influences on Sleep, Pain, and Depression Symptoms in a Community Sample of Twins.
Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
- Dopamine transporter gene (Pain reports · 2026Article
- Joint association of chronic pain and sleep patterns with cardiovascular diseases: a prospective study.BMC public health · 2026Article
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
- The Interplay Between Sleep and Mental Health: A Genetic Perspective.Biological psychiatry · 2025Review
- Psycho-Socio-Behavioural Substrates of Non-Cancer Chronic Pain: A Twin Study in Italian Adults.Journal of pain research · 2025Article
- Sleep and psychiatric disorders: Bidirectional interactions and shared neurobiological mechanisms.PLOS mental health · 2025Review
- Sleep duration and pain during the COVID-19 pandemic with depression and chronic diseases as mediators.Scientific reports · 2024Article
- The effect of community environment on the trajectory of depressive symptoms and cohort differences among middle-aged and older Chinese adults.Frontiers in public health · 2024Article
- The mediating role of sleep disturbance in the relationship between depression and cardiovascular disease.Frontiers in psychiatry · 2024Article
- Latent patterns of sleep disturbance, pain impact, and depressive symptoms in residential substance use treatment.Drug and alcohol dependence · 2023Article
- Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain: a DOLORisk Dundee study.Journal of neurology · 2023Article
- Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits.Sleep · 2022Review
- Nature and nurture. Genetic and environmental factors on the relationship between back pain and sleep quality.European journal of pain (London, England) · 2022Article
- Association of Depressive Symptoms with Sleep Disturbance: A Co-twin Control Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022Article
- The P-factor and its genomic and neural equivalents: an integrated perspective.Molecular psychiatry · 2022Review
- Associations of sleep with psychological problems and well-being in adolescence: causality or common genetic predispositions?Journal of child psychology and psychiatry, and allied disciplines · 2021Article
- Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance.Translational psychiatry · 2020Article
- Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions.Communications biology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveWe used quantitative genetic methods to evaluate whether sleep quality, pain, and depression symptoms share a common genetic diathesis, to estimate the genetic and environmental sources of covariance among these symptoms, and to test for possible causal relationships.
methodsA community sample of 400 twins from the University of Washington Twin Registry completed standardized self-report questionnaires. We used biometric modeling to assess genetic and environmental contribution to the association between sleep quality measured by the Pittsburgh Sleep Quality Index, pain measured by the Brief Pain Inventory, and depression symptoms measured by the Brief Symptom Inventory. Trivariate Cholesky structural equation models were used to decompose correlations among the phenotypes.
resultsHeritability was estimated at 37% (95% confidence interval = 20%-51%) for sleep quality, 25% (9%-41%) for pain, and 39% (22%-53%) for depression. Nonshared environmental influences accounted for the remaining variance. The genetic correlation between sleep quality and pain had an rg value of .69 (95% confidence interval [CI] = 0.33-0.97), rg value of .56 (95% CI = 0.55-0.98) between pain and depression, and rg value of .61 (95% CI = 0.44-0.88) between depression and sleep quality. Nonshared environmental overlap was present between pain and sleep quality as well as depression and sleep quality.
conclusionsThe link between sleep quality, pain, and depression was primarily explained by shared genetic influences. The genetic factors influencing sleep quality and pain were highly correlated even when accounting for depression. Findings support the hypothesis of a genetic link between depression and pain as well as potential causality for the association of sleep quality with pain and depression.
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