Observational studyMedicine2017
Association between periodontal disease and non-communicable diseases: A 12-year longitudinal health-examinee cohort study in South Korea.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 6 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Periodontitis as an independent risk factor for cardiovascular disease: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Periodontal disease and subsequent risk of cardiovascular outcome and all-cause mortality: A meta-analysis of prospective studies.PloS one · 2023Pooled it
- Obesity and periodontitis: A systematic review and updated meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies.Scientific reports · 2021Pooled it
- Risk of incident cardiovascular disease in people with periodontal disease: A systematic review and meta-analysis.Clinical and experimental dental research · 2021Pooled it
- Definitions used for a healthy periodontium-A systematic review.International journal of dental hygiene · 2020Pooled it
- Periodontal Disease and Osteoporosis: A Bidirectional Relationship.Advances in experimental medicine and biology · 2026Review
- Attempts to Modify Periodontal Screening Models Based on a Self-Reported Oral Health Questionnaire in the Medical Care Setting.Journal of clinical periodontology · 2025Article
- Longitudinal association between dentition status and gait speed among older Brazilian adults: SABE cohort study.BMC geriatrics · 2024Article
- Psychological Stress and its relationship to Periodontal flora and salivary Nitrite/Nitrate.International dental journal · 2024Article
- Clinical attachment loss is cross-sectionally associated with elevated glucose among adults without diabetes.Journal of clinical periodontology · 2024Article
- NLRP3 Inflammasome in Autoinflammatory Diseases and Periodontitis Advance in the Management.Journal of pharmacy & bioallied sciences · 2024Review
- Article
- Bidirectional associations between periodontal disease and systemic diseases: a nationwide population-based study in Korea.Scientific reports · 2023Article
- Periodontal Diseases and Heart Diseases: A Systemic Review.Journal of pharmacy & bioallied sciences · 2023Article
- The Effect of Non-Surgical Periodontal Treatment on Patients with Combined Refractory Arterial Hypertension and Stage III, Grade B Periodontitis: A Preliminary Prospective Clinical Study.Journal of clinical medicine · 2023Article
- The association of periodontal disease and oral health with hypertension, NHANES 2009-2018.BMC public health · 2023Article
- Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence.Metabolites · 2022Review
- A brief review of vitamin D as a potential target for the regulation of blood glucose and inflammation in diabetes-associated periodontitis.Molecular and cellular biochemistry · 2022Review
- Retrospective analysis of the effects of non-communicable diseases on periodontitis treatment outcomes.Journal of periodontal & implant science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The National Health Insurance Service-Health Examinee Cohort during 2002 to 2013 was used to investigate the associations between periodontal disease (PD) and the following non-communicable diseases (NCDs): hypertension, diabetes mellitus, osteoporosis, cerebral infarction, angina pectoris, myocardial infarction, and obesity.Univariate and multivariate logistic regression analyses adjusting for potential confounders during the follow-up period-including age, sex, household income, insurance status, residence area, health status, and comorbidities-were used to estimated odds ratios (ORs) with 95% confidence intervals (CIs) in order to assess the associations between PD and NCDs.We enrolled 200,026 patients with PD and 154,824 subjects with a healthy oral status. Statistically, significant associations were found between PD and the investigated NCDs except for cerebral and myocardial infarction after adjusting for sociodemographic and comorbidity factors (P < .05). In particular, obesity (OR = 1.30, 95% CI = 1.04-1.63, P = .022), osteoporosis (OR = 1.22, 95% CI = 1.18-1.27, P < .001), and angina pectoris (OR = 1.22, 95% CI = 1.17-1.27, P < .001) were significantly and positively associated with PD.This longitudinal cohort study has provided evidence that patients with PD are at increased risk of NCDs. Further studies are required to confirm the reliability of this association and elucidate the role of the inflammatory pathway in periodontitis pathogenesis as a triggering and mediating mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.