SynthesisMedicine2017
Effects of atorvastatin on chronic subdural hematoma: A systematic review.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07144423 (Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma: A Multicenter Randomized Controlled Trial, URANUS
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Middle meningeal artery embolization for chronic subdural hematoma: a systematic review.Frontiers in neurology · 2023Pooled it
- Pharmacological Treatment in the Management of Chronic Subdural Hematoma.Frontiers in aging neuroscience · 2021Pooled it
- From burr-hole to embolization: unveiling the evolution of chronic subdural hematoma research (2001-2025).Frontiers in neurologyPooled it
- A Prospective Randomized Study on the Preventive Effect of Japanese Herbal Kampo Medicine Goreisan for Recurrence of Chronic Subdural Hematoma.Neurologia medico-chirurgica · 2021Trial
- Safety and Efficacy of Atorvastatin for Chronic Subdural Hematoma in Chinese Patients: A Randomized ClinicalTrial.JAMA neurology · 2018Trial
- Establishment of a novel rat model of chronic subdural hematoma: Recapitulating human pathological features through triple-component induction.IBRO neuroscience reports · 2026Article
- Pre-surgery statin use and outcomes in operated chronic subdural haematomas: a nationwide cohort study.Age and ageing · 2026Article
- Management of chronic subdural hematoma: a consensus statement from the 2024 Copenhagen joint iCORIC/DACSUHS symposium.Acta neurochirurgica · 2026Review
- Impact of Antivascular Endothelial Growth Factor Therapy in Chronic Subdural Hematoma Patients: A Propensity-Matched Multi-Institutional Cohort Study.Stroke (Hoboken, N.J.) · 2026Article
- Atorvastatin inhibits ischemia‒reperfusion-associated renal tubular cell ferroptosis by blocking the PGE2/EP4 signaling pathway.In vitro cellular & developmental biology. Animal · 2025Article
- Letter to the Editor Concerning ''Risk Factors for the Recurrence of Chronic Subdural Hematoma".Korean journal of neurotrauma · 2025Article
- Photon counting CT vs. flat-panel CT in the evaluation of enhancement patterns in chronic subdural hematoma after middle meningeal artery embolization.Frontiers in neurology · 2025Article
- Prognostic significance of systemic inflammation response index, systemic immune-inflammation index and neutrophil-to-lymphocyte ratio in patients with chronic subdural hematoma after burr hole drainage.Frontiers in neurology · 2025Article
- Retrospective Analysis of Risk Factors for Recurrence of Chronic Subdural Haematoma after Surgery.Journal of clinical medicine · 2024Article
- Simultaneous determination of the combined and free concentrations of atorvastatin and its major metaboliteFrontiers in cardiovascular medicine · 2024Article
- Potential impact of high-density lipoprotein cholesterol in the postoperative outcomes of chronic subdural hematoma patients: multi-institutional study in Korea.Lipids in health and disease · 2023Observational
- Immunometabolic Profiling of Chronic Subdural Hematoma through Untargeted Mass Spectrometry Analysis: Preliminary Findings of a Novel Approach.Diagnostics (Basel, Switzerland) · 2023Article
- Craniocervical Manual Lymphatic Drainage Increases the Efficiency of Atorvastatin-Based Treatment of Chronic Subdural Hematoma.Translational stroke research · 2023Article
- Role of Adjunctive Tranexamic Acid in Facilitating Resolution of Chronic Subdural Hematoma after Surgery.Journal of Korean Neurosurgical Society · 2023Article
- Embolization of the middle meningeal artery vs. second surgery-treatment response and volume course of recurrent chronic subdural hematomas.Acta neurochirurgica · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe high recurrent rate of chronic subdural hematoma (CSDH) has consistently confused the neurosurgeons, and the role of atorvastatin in the management of CSDH has remained unclear over past decade, and atorvastatin seems to be a safe and cost-effective treatment to CSDH. Therefore, it is necessary to conduct a systematic review to discuss the effect of atorvastatin in CSDH.
methodWe searched the PubMed, EMBASE, Cochrane Library, and the China Biology Medicine disc, up to March 2017, for published studies on the effects of atorvastatin in the management of CSDH, and reviewers performed a brief qualitative descriptive analysis of atorvastatin's efficacy in the management of CSDH.
resultsThree eligible studies were included in this systematic review. Results indicated that atorvastatin accelerated hematoma absorption, decreased recurrence risk, and surgical requirement.
conclusionLimited evidence suggests that oral atorvastatin may be beneficial in the management of CSDH. Further high-quality studies focused on dosage, duration, hematoma size are needed to further elucidate the role of atorvastatin in the management of CSDH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.