Evidence map›Paper›PMID 28657937›Full record

Trial reportAnnals of surgery2018

Laparoscopic Versus Open Resection for Colorectal Liver Metastases: The OSLO-COMET Randomized Controlled Trial.

Åsmund Avdem Fretland, Vegar Johansen Dagenborg, Gudrun Maria Waaler Bjørnelv, Airazat M Kazaryan, Ronny Kristiansen, Morten Wang Fagerland, John Hausken, Tor Inge Tønnessen, Andreas Abildgaard, Leonid Barkhatov and 7 more

2 registry-linked trialsOpen access · greenAbstract readComparative StudyRandomized Controlled TrialEquivalence Trial
PubMed Publisher
In one paragraph

Trial report in Annals of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 322 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
322citing papers in PubMed, 10 pooled it
34.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04163887 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effect of the Laparoscopic Approach in Reducing Postoperative Severe Complications Following Hepatectomy for Colorectal Liver Metastases: Prospective, Randomized, Controlled Study

TypeinterventionalSponsorInstitut Mutualiste MontsourisRan2021 to 2026Enrolled340ConditionsLiver Metastasis Colon Cancer, Postoperative ComplicationsArmshepatectomy
NCT06562179 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Prospective, Single-Center Investigation of the da Vinci SP® Surgical System in Hepatopancreaticobiliary and Foregut Operations for Benign and Malignant Disease.

TypeinterventionalSponsorAdventHealthRan2024 to 2030Enrolled35ConditionsHepatopancreaticobiliary and Foregut OperationsArmsda Vinci SP® Single-Port Robotic Surgical System
3 · Its place in the literature

Who cites it

322 citing papers in PubMed, 10 syntheses or guidelines pooled it, 674 citations in OpenAlex.

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  14. Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
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262 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Åsmund Avdem FretlandThe Intervention Center, Oslo University Hospital, Oslo, Norway.
Vegar Johansen DagenborgDepartment of Tumor Biology, Oslo University Hospital, Oslo, Norway.
Gudrun Maria Waaler BjørnelvThe Intervention Center, Oslo University Hospital, Oslo, Norway.
Airazat M KazaryanDepartment of Gastrointestinal Surgery, Akershus University Hospital, Lørenskog, Norway.
Ronny KristiansenThe Intervention Center, Oslo University Hospital, Oslo, Norway.
Morten Wang FagerlandOslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
John HauskenDivision of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Tor Inge TønnessenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Andreas AbildgaardDepartment of Radiology, Oslo University Hospital, Oslo, Norway.
Leonid BarkhatovThe Intervention Center, Oslo University Hospital, Oslo, Norway.
Sheraz YaqubDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
Bård I RøsokDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
Bjørn Atle BjørnbethDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
Marit Helen AndersenDepartment of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
Kjersti FlatmarkDepartment of Gastroenterological Surgery, Oslo University Hospital, Oslo, Norway.
Eline AasInstitute of Health and Society, University of Oslo, Oslo, Norway.
Bjørn EdwinThe Intervention Center, Oslo University Hospital, Oslo, Norway.
Oslo University Hospital · NOUniversity of Oslo · NOAkershus University Hospital · NOVestre Viken Hospital Trust · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo perform the first randomized controlled trial to compare laparoscopic and open liver resection. SUMMARY BACKGROUND DATA: Laparoscopic liver resection is increasingly used for the surgical treatment of liver tumors. However, high-level evidence to conclude that laparoscopic liver resection is superior to open liver resection is lacking.

methodsExplanatory, assessor-blinded, single center, randomized superiority trial recruiting patients from Oslo University Hospital, Oslo, Norway from February 2012 to January 2016. A total of 280 patients with resectable liver metastases from colorectal cancer were randomly assigned to undergo laparoscopic (n = 133) or open (n = 147) parenchyma-sparing liver resection. The primary outcome was postoperative complications within 30 days (Accordion grade 2 or higher). Secondary outcomes included cost-effectiveness, postoperative hospital stay, blood loss, operation time, and resection margins.

resultsThe postoperative complication rate was 19% in the laparoscopic-surgery group and 31% in the open-surgery group (12 percentage points difference [95% confidence interval 1.67-21.8; P = 0.021]). The postoperative hospital stay was shorter for laparoscopic surgery (53 vs 96 hours, P < 0.001), whereas there were no differences in blood loss, operation time, and resection margins. Mortality at 90 days did not differ significantly from the laparoscopic group (0 patients) to the open group (1 patient). In a 4-month perspective, the costs were equal, whereas patients in the laparoscopic-surgery group gained 0.011 quality-adjusted life years compared to patients in the open-surgery group (P = 0.001).

conclusionsIn patients undergoing parenchyma-sparing liver resection for colorectal metastases, laparoscopic surgery was associated with significantly less postoperative complications compared to open surgery. Laparoscopic resection was cost-effective compared to open resection with a 67% probability. The rate of free resection margins was the same in both groups. Our results support the continued implementation of laparoscopic liver resection.

Indexed as

LaparoscopyAgedColorectal NeoplasmsFemaleFollow-Up StudiesHepatectomyHumansLiver NeoplasmsMaleMiddle AgedPostoperative ComplicationsSingle-Blind MethodTreatment Outcome

Identifiers

PMID28657937
OpenAlexW2733996396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.