Evidence map›Paper›PMID 28657906›Full record

ReviewPhysics in medicine and biology2017

Radiogenomics and radiotherapy response modeling.

Issam El Naqa, Sarah L Kerns, James Coates, Yi Luo, Corey Speers, Catharine M L West, Barry S Rosenstein, Randall K Ten Haken

Open access · greenAbstract readReview
In one paragraph

Review in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy.International journal of radiation oncology, biology, physics · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Uniqueness of radiomic features in non-small cell lung cancer.Journal of applied clinical medical physics · 2022
    Article
  12. Review
  13. Review
  14. Molecular Biology in Treatment Decision Processes-Neuro-Oncology Edition.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Roadmap: proton therapy physics and biology.Physics in medicine and biology · 2021
    Review
  17. Article
  18. Article
  19. Radiomics for liver tumours.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Issam El NaqaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States of America.ORCID 0000-0001-6023-1132
Sarah L KernsDepartment of Radiation Oncology, University of Rochester, Rochester, NY, United States of America.
James CoatesDepartment of Oncology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4908-0975
Yi LuoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States of America.
Corey SpeersDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States of America.
Catharine M L WestDivision of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital NHS Trust, University of Manchester, Manchester, United Kingdom.
Barry S RosensteinDepartments of Radiation Oncology and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Randall K Ten HakenDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States of America.
University of Michigan · USIcahn School of Medicine at Mount Sinai · USManchester Academic Health Science Centre · GBUniversity of Oxford · GBUniversity of Rochester · US

Funding

TREATMENT VERIFICATION AND TREATMENT PLAN REFINEMENTP01CA059827 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWRENCE, THEODORE S, TEN HAKEN, RANDALL K · 1993 to 2018
$37.9M
Genome-Wide Study to Identify SNPs and CNPs Associated with Radiation InjuryR01CA134444 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OSTRER, HARRY, ROSENSTEIN, BARRY S · 2009 to 2012
$2.3M
Risk Prediction for Development of Adverse Effects FOllowing Radiotherapy for Prostate CancerK07CA187546 · NCI · UNIVERSITY OF ROCHESTER · PI KERNS, SARAH L. · 2015 to 2019
$649k
Cancer Research UK 18504NCI NIH HHS HHSN261201500043CNCI NIH HHS K07 CA187546NCI NIH HHS P01 CA059827NCI NIH HHS R01 CA134444
6 · The paper itself

Abstract

Advances in patient-specific information and biotechnology have contributed to a new era of computational medicine. Radiogenomics has emerged as a new field that investigates the role of genetics in treatment response to radiation therapy. Radiation oncology is currently attempting to embrace these recent advances and add to its rich history by maintaining its prominent role as a quantitative leader in oncologic response modeling. Here, we provide an overview of radiogenomics starting with genotyping, data aggregation, and application of different modeling approaches based on modifying traditional radiobiological methods or application of advanced machine learning techniques. We highlight the current status and potential for this new field to reshape the landscape of outcome modeling in radiotherapy and drive future advances in computational oncology.

Indexed as

Models, BiologicalGenomicsHumansNeoplasmsRadiobiologyTreatment Outcome

Identifiers

PMID28657906
PMCPMC5557376
OpenAlexW2726701108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.