Evidence map›Paper›PMID 28657607›Full record

ReviewNutrients2017

Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy.

Rosita Aitoro, Lorella Paparo, Antonio Amoroso, Margherita Di Costanzo, Linda Cosenza, Viviana Granata, Carmen Di Scala, Rita Nocerino, Giovanna Trinchese, Mariangela Montella and 2 more

Abstract readReview
In one paragraph

Review in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Frontiers in pediatrics · 2021
    Pooled it
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  12. [Specific changes in gut microbiota and short-chain fatty acid levels in infants with cow's milk protein allergy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rosita AitoroDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. aitoro.rosita@gmail.com.
Lorella PaparoDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. paparolorella@gmail.com.
Antonio AmorosoDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. antonioamoroso87@gmail.com.
Margherita Di CostanzoDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. mara.dicostanzo@live.it.
Linda CosenzaDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. lindacosenza@libero.it.
Viviana GranataDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. vivianagranata@gmail.com.
Carmen Di ScalaDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. carmendiscala@gmail.com.
Rita NocerinoDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. ritanocerino@alice.it.
Giovanna TrincheseDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. giovanna.trinchese@unina.it.
Mariangela MontellaDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. mariangelamontella@libero.it.
Danilo ErcoliniDepartment of Agricultural Sciences, Division of Microbiology, University of Naples "Federico II", 80055 Portici, Italy. ercolini@unina.it.
Roberto Berni CananiDepartment of Translational Medical Science-Pediatric Section, University of Naples "Federico II", 80131 Naples, Italy. berni@unina.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota plays a pivotal role in immune system development and function. Modification in the gut microbiota composition (dysbiosis) early in life is a critical factor affecting the development of food allergy. Many environmental factors including caesarean delivery, lack of breast milk, drugs, antiseptic agents, and a low-fiber/high-fat diet can induce gut microbiota dysbiosis, and have been associated with the occurrence of food allergy. New technologies and experimental tools have provided information regarding the importance of select bacteria on immune tolerance mechanisms. Short-chain fatty acids are crucial metabolic products of gut microbiota responsible for many protective effects against food allergy. These compounds are involved in epigenetic regulation of the immune system. These evidences provide a foundation for developing innovative strategies to prevent and treat food allergy. Here, we present an overview on the potential role of gut microbiota as the target of intervention against food allergy.

Indexed as

Gastrointestinal MicrobiomeDietDietary FiberDiet, High-FatDysbiosisEpigenesis, GeneticFood HypersensitivityHumansImmune SystemInfantMetabolomicsProbioticsDietary Fiberbutyratecow’s milk allergydietdysbiosisimmune toleranceprobioticsshort chain fatty acids

Identifiers

PMID28657607
PMCPMC5537787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.