ReviewJournal of gynecologic oncology2017
Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study.
Review in Journal of gynecologic oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Disseminated relapse of ovarian mature cystic teratoma with squamous cell carcinoma transformation following intraoperative spillage: a case report.International journal of surgery case reports · 2026Article
- Human Papillomavirus-Induced Keratinizing Squamous Cell Carcinoma in Ovarian Cystic Teratoma: A Case Report and Literature Review.International journal of women's health · 2026Article
- Prognostic factors for malignant tumors arising from mature cystic teratomas: a study involving the Kansai Clinical Oncology Group (KCOG-G1305s study).Archives of gynecology and obstetrics · 2025Article
- Spinal teratoma in an adolescent: a rare case report with intradural presentation and review of management strategies.Annals of medicine and surgery (2012) · 2025Article
- Malignant transformation of an ovarian mature teratoma diagnosed 17 years ago: a case report and literature review of treatment with immune checkpoint inhibitors.International cancer conference journal · 2025Article
- Review
- MRI findings of malignant transformation arising from mature cystic teratoma of the ovary: comparison with benign mature cystic teratoma.Japanese journal of radiology · 2024Article
- Article
- Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature.Journal of medical case reports · 2024Review
- Malignant Transformation in a Mature Cystic Teratoma of the Ovary: A 5-year Descriptive Study.Acta medica Philippina · 2024Article
- Pediatric puzzle: Large ovarian dermoid cyst and markedly elevated CA 19-9 in an 8-year-old.Qatar medical journal · 2024Article
- Mucinous intestinal adenocarcinoma arising from mature cystic teratoma of the ovary treated with FOLFOX-6 - a case report.Ecancermedicalscience · 2024Article
- Somatic Malignant Transformation in Ovarian Mature Cystic Teratoma - Case Series from a Tertiary Cancer Centre in India.Indian journal of surgical oncology · 2023Article
- BRCA germline mutations in multiethnic gynecologic patients: A 10-year retrospective analysis from a single cancer institute.PloS one · 2023Article
- A rare case of squamous cell carcinoma transformation in a mature cystic teratoma of the ovary.SAGE open medical case reports · 2023Article
- Malignant Transformation of Unknown Duration of an Ovarian Mature Cystic Teratoma Presenting as a Trocar Recurrence in a Young Patient: A Case Report and Literature Review.Case reports in obstetrics and gynecology · 2023Article
- Review
- Malignant transformation of primary mature teratoma of colon: A case report.World journal of clinical cases · 2022Article
- Stage Ia squamous cell carcinoma as the malignant transformation of giant and unusual mature teratoma of the ovary in an elderly patient.Journal of ovarian research · 2022Article
- O-RADS MRI Risk Stratification System: Guide for Assessing Adnexal Lesions from the ACR O-RADS Committee.Radiology · 2022Review
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe malignant transformation (MT) of ovarian mature cystic teratoma (MCT) to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiple medical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, and prognostic factors of this disease and reviewed related literature.
methodsPathological reports of 16,001 patients with primary ovarian cancer who were treated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients with MT of MCT to SCC were identified.
resultsAmong all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age of patients was 52 years (range, 29-89 years), and the mean tumor size was 10.5 cm (range, 1-40 cm). We analyzed the patients in our study and those in the literature and determined that early identification and complete surgical resection of the tumor are essential for long-term survival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be used to treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTs are suitable indicators predicting the risk of MT of MCT to SCC.
conclusionSimilar to general epithelial ovarian cancers, the early detection of MT of MCT to SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should be evaluated to exclude potential MT to SCC.
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