ArticleHuman brain mapping2017
Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington's disease.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Artificial Intelligence and Neuroscience: Transformative Synergies in Brain Research and Clinical Applications.Journal of clinical medicine · 2025Review
- Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment.JAMA network open · 2024Article
- Progressive alterations in white matter microstructure across the timecourse of Huntington's disease.Brain and behavior · 2023Article
- Brain Alterations in Aged OVT73 Sheep Model of Huntington's Disease: An MRI Based Approach.Journal of Huntington's disease · 2022Article
- Neurocognitive Features of Motor Premanifest Individuals With Myotonic Dystrophy Type 1.Neurology. Genetics · 2021Article
- Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease.NeuroImage. Clinical · 2021Article
- Diffusion imaging in Huntington's disease: comprehensive review.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- Six Visual Rating Scales as A Biomarker for Monitoring Atrophied Brain Volume in Parkinson's Disease.Aging and disease · 2020Article
- Dual tasking impairments are associated with striatal pathology in Huntington's disease.Annals of clinical and translational neurology · 2020Article
- Association of CAG Repeats With Long-term Progression in Huntington Disease.JAMA neurology · 2019Article
- Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration.Journal of neurology · 2019Review
- Progressive microstructural changes of the occipital cortex in Huntington's disease.Brain imaging and behavior · 2018Article
- Novel Imaging Biomarkers for Huntington's Disease and Other Hereditary Choreas.Current neurology and neuroscience reports · 2018Review
- Natural biological variation of white matter microstructure is accentuated in Huntington's disease.Human brain mapping · 2018Article
- Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI-Application in Premanifest Huntington's Disease.Journal of visualized experiments : JoVE · 2018Article
- An image-based model of brain volume biomarker changes in Huntington's disease.Annals of clinical and translational neurology · 2018Article
- Genetics Modulate Gray Matter Variation Beyond Disease Burden in Prodromal Huntington's Disease.Frontiers in neurology · 2018Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that progressively affects motor, cognitive, and emotional functions. Structural MRI studies have demonstrated brain atrophy beginning many years prior to clinical onset ("premanifest" period), but the order and pattern of brain structural changes have not been fully characterized. In this study, we investigated brain regional volumes and diffusion tensor imaging (DTI) measurements in premanifest HD, and we aim to determine (1) the extent of MRI changes in a large number of structures across the brain by atlas-based analysis, and (2) the initiation points of structural MRI changes in these brain regions. We adopted a novel multivariate linear regression model to detect the inflection points at which the MRI changes begin (namely, "change-points"), with respect to the CAG-age product (CAP, an indicator of extent of exposure to the effects of CAG repeat expansion). We used approximately 300 T1-weighted and DTI data from premanifest HD and control subjects in the PREDICT-HD study, with atlas-based whole brain segmentation and change-point analysis. The results indicated a distinct topology of structural MRI changes: the change-points of the volumetric measurements suggested a central-to-peripheral pattern of atrophy from the striatum to the deep white matter; and the change points of DTI measurements indicated the earliest changes in mean diffusivity in the deep white matter and posterior white matter. While interpretation needs to be cautious given the cross-sectional nature of the data, these findings suggest a spatial and temporal pattern of spread of structural changes within the HD brain. Hum Brain Mapp 38:5035-5050, 2017. © 2017 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.