ReviewThe Journal of physiology2018
The role of skeletal muscle contractile duration throughout the whole day: reducing sedentary time and promoting universal physical activity in all people.
Review in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between sedentary behavior and dementia: a systematic review and meta-analysis of cohort studies.BMC psychiatry · 2025Pooled it
- Successfully Reducing Sitting Time Can Improve Metabolic Flexibility.Scandinavian journal of medicine & science in sports · 2025Trial
- Responsiveness of electromyographically assessed skeletal muscle inactivity: methodological exploration and implications for health benefits.Scientific reports · 2022Trial
- Causal associations between lifestyle factors and hemorrhoidal disease: Insights from Mendelian randomization analysis.Medicine · 2026Article
- Impact of nutrition on long COVID.Sports medicine and health science · 2026Review
- Sex differences in the impact of sedentary time on early-onset metabolic multimorbidity: evidence from a study of over 20,000 young adults.Biology of sex differences · 2026Article
- Sedentary behavior and metabolic health in young adults across ecological contexts and behavioral patterns.Scientific reports · 2025Article
- Sedentary Time and Breast Cancer Risk in the Sister Study Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Silence of the Muscles: Wearable Electromyography, Sitting, and Type 2 Diabetes.Exercise and sport sciences reviews · 2025Review
- Physiological processes induced by different types of physical activity that either oppose or enhance postprandial glucose tolerance.Frontiers in endocrinology · 2025Review
- Mechanisms Underlying the Rarity of Skeletal Muscle Cancers.International journal of molecular sciences · 2024Review
- Sedentary behavior, physical activity, sleep duration and obesity risk: Mendelian randomization study.PloS one · 2024Article
- Exercise breaks prevent attenuation in cerebrovascular function following an acute bout of uninterrupted sitting in healthy children.Experimental physiology · 2023Article
- Protocol for a study on Sitting with Interruption and Whole-Body Cardiovascular Health (SWITCH) in middle-aged adults.Contemporary clinical trials · 2023Article
- Role of leisure sedentary behavior on type 2 diabetes and glycemic homeostasis: a Mendelian randomization analysis.Frontiers in endocrinology · 2023Article
- The Effect of Breaking Up Sedentary Time with Calisthenics on Neuromuscular Function: A Preliminary Study.International journal of environmental research and public health · 2022Article
- Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Acute Effects of Sedentary Behavior on Ankle Torque Assessed with a Custom-Made Electronic Dynamometer.Journal of clinical medicine · 2022Article
- Television viewing time and all-cause mortality: interactions with BMI, physical activity, smoking, and dietary factors.The international journal of behavioral nutrition and physical activity · 2022Article
- Sedentary lifestyle and body composition in type 2 diabetes.Diabetology & metabolic syndrome · 2022Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A shared goal of many researchers has been to discover how to improve health and prevent disease, through safely replacing a large amount of daily sedentary time with physical activity in everyone, regardless of age and current health status. This involves contrasting how different muscle contractile activity patterns regulate the underlying molecular and physiological responses impacting health-related processes. It also requires an equal attention to behavioural feasibility studies in extremely unfit and sedentary people. A sound scientific principle is that the body is constantly sensing and responding to changes in skeletal muscle metabolism induced by contractile activity. Because of that, the rapid time course of health-related responses to physical inactivity/activity patterns are caused in large part directly because of the variable amounts of muscle inactivity/activity throughout the day. However, traditional modes and doses of exercise fall far short of replacing most of the sedentary time in the modern lifestyle, because both the weekly frequency and the weekly duration of exercise time are an order of magnitude less than those for people sitting inactive. This can explain why high amounts of sedentary time produce distinct metabolic and cardiovascular responses through inactivity physiology that are not sufficiently prevented by low doses of exercise. For these reasons, we hypothesize that maintaining a high metabolic rate over the majority of the day, through safe and sustainable types of muscular activity, will be the optimal way to create a healthy active lifestyle over the whole lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.