Evidence map›Paper›PMID 28656627›Full record

ArticleAddiction biology2018

CB

Dean Kirson, Christopher Shaun Oleata, Loren Howell Parsons, Roberto Ciccocioppo, Marisa Roberto

Abstract read
In one paragraph

Article in Addiction biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The Role of the Central Amygdala in Alcohol Dependence.Cold Spring Harbor perspectives in medicine · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. The role of BDNF methylation and ValHuman brain mapping · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Dean KirsonDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California, USA.
Christopher Shaun OleataDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California, USA.
Loren Howell ParsonsDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California, USA.
Roberto CiccocioppoSchool of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy.
Marisa RobertoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California, USA.ORCID 0000-0003-0729-3961
Scripps Research Institute · USUniversità di Camerino · IT

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2003 to 2026
$46.3M
Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI RIVIER, CATHERINE L · 1985 to 2002
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
Oxytocin effects on GABAergic signaling in the alcohol dependent CeA.F32AA025262 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI KIRSON, DEAN · 2016 to 2017
$46k
NIAAA NIH HHS F32 AA025262NIAAA NIH HHS P50 AA006420NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R37 AA017447NIAAA NIH HHS T32 AA007456NIAAA NIH HHS U01 AA013498
6 · The paper itself

Abstract

The central amygdala (CeA) is involved in the processing of anxiety and stress and plays a role in ethanol consumption. Chronic ethanol recruits stress systems in the CeA, leading to aversive withdrawal symptoms. Although primarily GABAergic, CeA contains glutamatergic afferents, and we have reported inhibitory effects of ethanol on locally evoked glutamatergic responses in CeA of Wistar and Marchigian Sardinian alcohol-preferring (msP) rats. Notably, msP rats display enhanced anxiety, stress and alcohol drinking, simulating the alcohol-dependent phenotype. Endocannabinoids are also involved in regulation of stress, and we previously demonstrated that cannabinoid receptor type 1 (CB

Indexed as

AnimalsBenzoxazinesCentral Amygdaloid NucleusCentral Nervous System DepressantsEthanolExcitatory Postsynaptic PotentialsFemaleGlutamic AcidMaleMorpholinesNaphthalenesPiperidinesPyrazolesRatsRats, WistarReceptor, Cannabinoid, CB1(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneAM 251BenzoxazinesCentral Nervous System DepressantsEthanolGlutamic AcidMorpholinesNaphthalenesPiperidinesPyrazolesReceptor, Cannabinoid, CB1CB1CeAeCBethanolglutamate

Identifiers

PMID28656627
PMCPMC5745318
OpenAlexW2734275402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.