Evidence map›Paper›PMID 28656502›Full record

ReviewCurrent oncology reports2017

Update on Treatment Options for Advanced Bile Duct Tumours: Radioembolisation for Advanced Cholangiocarcinoma.

Pavan Najran, Angela Lamarca, Damian Mullan, Mairéad G McNamara, Thomas Westwood, Richard A Hubner, Jeremy Lawrence, Prakash Manoharan, Jon Bell, Juan W Valle

Open access · hybridAbstract readReview
In one paragraph

Review in Current oncology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Progress toward improving outcomes in patients with cholangiocarcinoma.Current treatment options in gastroenterology · 2021
    Article
  6. Article
  7. OncoTargets and therapy · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Pavan NajranDepartment of Radiology, The Christie NHS Foundation Trust, Manchester, UK.
Angela LamarcaDepartment of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK.
Damian MullanDepartment of Radiology, The Christie NHS Foundation Trust, Manchester, UK.
Mairéad G McNamaraDepartment of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK.
Thomas WestwoodDepartment of Radiology, The Christie NHS Foundation Trust, Manchester, UK.
Richard A HubnerDepartment of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK.
Jeremy LawrenceDepartment of Radiology, The Christie NHS Foundation Trust, Manchester, UK.
Prakash ManoharanDepartment of Radiology, The Christie NHS Foundation Trust, Manchester, UK.
Jon BellDepartment of Radiology, The Christie NHS Foundation Trust, Manchester, UK.
Juan W ValleDepartment of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK. juan.valle@christie.nhs.uk.
The Christie NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholangiocarcinoma is a rare form of gastrointestinal cancer with a poor prognosis. Patients often present with biliary obstruction or non-specific abdominal pain, and a high proportion of patients have advanced disease at initial diagnosis. The goal of this review is to discuss treatment options for patients with advanced bile duct tumours focusing on radioembolisation (RE) and its impact on overall survival. RE provides a therapeutic option for patients with unresectable cholangiocarcinoma. However, although systemic chemotherapy has demonstrated a survival benefit in randomised controlled trials, there is limited supporting evidence for the use of RE in this setting. Studies are mostly limited to single-centre, small cohorts with variable outcome measures. Additionally, patients included in these studies received a variety of previous therapies including chemotherapy, surgery or alternative intra-arterial therapy; therefore, a true assessment of overall survival benefit is difficult.

Indexed as

Bile Duct NeoplasmsCatheter AblationCholangiocarcinomaDisease-Free SurvivalGastrointestinal NeoplasmsHumansNeoplasm StagingRandomized Controlled Trials as TopicTreatment OutcomeAdvancedChemotherapyCholangiocarcinomaIntrahepaticLiver radioembolisation (RE)Treatment

Identifiers

PMID28656502
PMCPMC5487900
OpenAlexW2602621655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.