ArticleHuman genetics2017
A genetic risk score is differentially associated with migraine with and without aura.
Article in Human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- What does a migraine aura look like?-A systematic review.The journal of headache and pain · 2025Pooled it
- Current Update on Categorization of Migraine Subtypes on the Basis of Genetic Variation: a Systematic Review.Molecular neurobiology · 2024Pooled it
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- The effects of transcutaneous auricular vagus nerve stimulation in epilepsy comorbid with migraine on the EEG power spectrum: a randomized controlled trial.Frontiers in neurology · 2025Article
- Exploratory study on autoantibodies to arginine-rich human peptides mimicking Epstein-Barr virus in women with post-COVID and myalgic encephalomyelitis/chronic fatigue syndrome.Frontiers in immunology · 2025Article
- Association between MAPK and PI3K/Akt signaling pathway-related gene polymorphisms and migraine.Molecular genetics & genomic medicine · 2024Article
- The Epigenetics of Migraine.International journal of molecular sciences · 2023Review
- Pharmacogenetics in Primary Headache Disorders.Frontiers in pharmacology · 2021Review
- Genetics of migraine aura: an update.The journal of headache and pain · 2020Review
- A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants.Drug development research · 2020Article
- Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort.Frontiers in genetics · 2020Article
- Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine.Current diabetes reports · 2019Review
- Linking migraine frequency with family history of migraine.Cephalalgia : an international journal of headache · 2019Article
- Article
- Are Migraine With and Without Aura Really Different Entities?Frontiers in neurology · 2019Review
- Article
- Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA.Acta neuropathologica communications · 2018Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
Although a number of migraine-associated single-nucleotide polymorphisms (SNP) with small effect size have been identified, little is known about the additive impact of these variants on migraine risk, frequency and severity. We investigated to what extent a genetic risk score (GRS) based on recently published, novel migraine-associated SNPs is associated with migraine prevalence, subtypes and severity in a large population-based sample. The sample comprised 446 subjects with migraine and 2511 controls from the CoLaus/PsyCoLaus study. Fifty-four SNPs earlier associated with migraine were selected. SNPs with a low impact on migraine prevalence in our sample were excluded using random forest. We combined the remaining 21 SNPs into a GRS and analyzed the association with migraine using logistic regression models. The GRS was significantly associated with migraine (OR = 1.56, p = 0.02) and migraine without aura (MWOA) (OR = 2.01, p = 0.003), but not with migraine with aura (MWA). The GRS was not associated with migraine frequency, intensity or interference with daily activities. We show that a GRS combining multiple genetic risk variants is associated with MWOA but not MWA, suggesting a different genetic susceptibility background underlying the two forms of migraine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.