ArticleBioMed research international2017
Reduction of Interhemispheric Functional Brain Connectivity in Early Blindness: A Resting-State fMRI Study.
Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Functional reorganization of the visual cortex in blindness: a connectivity perspective.Frontiers in human neuroscience · 2026Review
- Gray matter abnormalities in sight deprivation and sight restoration.Brain structure & function · 2025Article
- Convergent reductions in interhemispheric functional, structural and callosal connectivity in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.Biomedicines · 2024Article
- Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study.Scientific reports · 2022Article
- Sight restoration reverses blindness-induced cross-modal functional connectivity changes between the visual and somatosensory cortex at rest.Frontiers in neuroscience · 2022Article
- Neuroimaging Markers of Chronic Eye Diseases and Their Application Values.Frontiers in neurology · 2022Review
- Grey Matter Hypertrophy and Atrophy in Early-Blind Adolescents: A Surface-Based Morphometric Study.Disease markers · 2022Article
- Topologic Reorganization of White Matter Connectivity Networks in Early-Blind Adolescents.Neural plasticity · 2022Article
- Abnormal interhemispheric resting state functional connectivity in Parkinson's disease patients with impulse control disorders.NPJ Parkinson's disease · 2021Article
- The effect of congenital blindness on resting-state functional connectivity revisited.Scientific reports · 2021Observational
- Interhemispheric Functional Connectivity Alterations in Diabetic Optic Neuropathy: A Resting-State Functional Magnetic Resonance Imaging Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Normal Olfactory Functional Connectivity Despite Lifelong Absence of Olfactory Experiences.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Altered Temporal Dynamic Intrinsic Brain Activity in Late Blindness.BioMed research international · 2020Article
- The homotopic connectivity of the functional brain: a meta-analytic approach.Scientific reports · 2019Article
- Alterations of the Brain Microstructure and Corresponding Functional Connectivity in Early-Blind Adolescents.Neural plasticity · 2019Article
- Reduced Dynamic Interactions Within Intrinsic Functional Brain Networks in Early Blind Patients.Frontiers in neuroscience · 2019Article
- Article
- Altered functional connectivity of primary visual cortex in late blindness.Neuropsychiatric disease and treatment · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to investigate the resting-state interhemispheric functional connectivity in early blindness by using voxel-mirrored homotopic connectivity (VMHC). MATERIALS AND
methodsSixteen early blind patients (EB group) and sixteen age- and gender-matched sighted control volunteers (SC group) were recruited in this study. We used VMHC to identify brain areas with significant differences in functional connectivity between different groups and used voxel-based morphometry (VBM) to calculate the individual gray matter volume (GMV).
resultsVMHC analysis showed a significantly lower connectivity in primary visual cortex, visual association cortex, and somatosensory association cortex in EB group compared to sighted controls. Additionally, VBM analysis revealed that GMV was reduced in the left lateral calcarine cortices in EB group compared to sighted controls, while it was increased in the left lateral middle occipital gyri. Statistical analysis showed the duration of blindness negatively correlated with VMHC in the bilateral middle frontal gyri, middle temporal gyri, and inferior temporal gyri.
conclusionsOur findings help elucidate the pathophysiological mechanisms of EB. The interhemispheric functional connectivity was impaired in EB patients. Additionally, the middle frontal gyri, middle temporal gyri, and inferior temporal gyri may be potential target regions for rehabilitation.
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