ArticleJournal of biomarkers2017
The Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin.
Article in Journal of biomarkers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- A clinical and experimental investigation of liraglutide effects on the brain-kidney axis.Science advances · 2026Article
- Absence of detectable circadian rhythmicity of neurophysin I, a surrogate marker for oxytocin.Pituitary · 2026Article
- Diurnal function and expression of aquaporins in the mouse kidney.American journal of physiology. Renal physiology · 2025Article
- The Chronobiology of Hormone Administration: "Doctor, What Time Should I Take My Medication?"Endocrine reviews · 2025Review
- Coffee intake and the vasopressin system: an epidemiological and experimental study.Endocrine connections · 2025Article
- Enhancing diagnostic tools for vasopressin deficiency: insights from a single-center cohort study.Pituitary · 2025Article
- Relationship between fluid intake, hydration status and cortisol dynamics in healthy, young adult males.Comprehensive psychoneuroendocrinology · 2025Article
- Circadian copeptin and oxytocin profiles in anorexia nervosa: Exploring the interplay with neurohypophysis opioid tone.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- New insights on diagnosis and treatment of AVP deficiency.Reviews in endocrine & metabolic disorders · 2024Review
- Long-term health outcomes associated with hydration status.Nature reviews. Nephrology · 2024Review
- Neuroendocrine response to diclofenac in healthy subjects: a pilot study.Journal of endocrinological investigation · 2023Article
- Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.The journal of physiological sciences : JPS · 2023Article
- Review novel insights into the diagnostic and prognostic function of copeptin in daily clinical practice.Molecular biology reports · 2023Review
- Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications.Balkan medical journal · 2023Article
- Copeptin in Growth Hormone-Treated Patients.Journal of clinical medicine · 2022Article
- Relevance of cortisol and copeptin blood concentration changes in an experimental pain model.Scientific reports · 2022Article
- Copeptin as a Diagnostic and Prognostic Biomarker in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022Review
- Distribution of plasma copeptin levels and influence of obesity in children and adolescents.European journal of pediatrics · 2021Article
- Copeptin and stress-induced hyperglycemia in critically ill patients: A prospective study.PloS one · 2021Article
- Hydration biomarkers and copeptin: relationship with ad libitum energy intake, energy expenditure, and metabolic fuel selection.European journal of clinical nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have investigated copeptin as a prognostic marker of different acute diseases and as a diagnostic marker in disorders of water and salt homeostasis. However, no data of the normal circadian rhythm of copeptin in healthy subjects are available.
aimTo investigate the circadian rhythm of copeptin in healthy subjects under standardized conditions.
methods19 healthy volunteers aged 18 to 53 years, male and female, were studied in a prospective observational study. In all 19 participants, blood samples for copeptin were taken in regular intervals of 30 minutes for 24 hours after a fasting period of minimum 8 hours.
resultsThe mean values of copeptin showed a circadian rhythm, similar to that described for AVP release, with a trend towards higher levels (5.9 ± 1 pmol/L) at night and early morning between 4 am and 6 am and lowest levels (2.3 ± 0.2 pmol/L) in the late afternoon between 5 pm and 7 pm. This finding was only observed in individuals with initial higher copeptin levels, whereas in individuals with lower basal copeptin levels no circadian rhythm was observed.
conclusionThere is evidence for a circadian rhythm in copeptin release during 24 hours, however, of minor extent. These findings suggest that copeptin levels can be determined irrespectively of the time of the day.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.