Evidence map›Paper›PMID 28656057›Full record

ArticleTheranostics2017

Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents.

Zhipeng Chen, Lei Xing, Qin Fan, Andrew G Cheetham, Ran Lin, Barbara Holt, Liwen Chen, Yanyu Xiao, Honggang Cui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Journal of the American Chemical Society · 2024
    Article
  5. Development of biomedical hydrogels for rheumatoid arthritis treatment.Asian journal of pharmaceutical sciences · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Self-Assembling Peptide-Based Hydrogels for Wound Tissue Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  10. Hydrogels for the treatment of rheumatoid arthritis.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. BH3-mimetics: recent developments in cancer therapy.Journal of experimental & clinical cancer research : CR · 2021
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. "Locked" cancer cells are more sensitive to chemotherapy.Bioengineering & translational medicine · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Zhipeng ChenJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Lei XingState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Qin FanJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Andrew G CheethamDepartment of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Ran LinDepartment of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Barbara HoltDepartment of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Liwen ChenDepartment of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Yanyu XiaoState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Honggang CuiDepartment of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA.
Johns Hopkins University · USChina Pharmaceutical University · CNNanjing University of Chinese Medicine · CN

Funding

FEI Tecnai F20 Transmission Electron Microscope for Core Microscopy FacilityS10OD012342 · OD · JOHNS HOPKINS UNIVERSITY · PI MCCAFFERY, J. MICHAEL · 2014 to 2014
$1.3M
6 · The paper itself

Abstract

We report here on the covalent conversion of the anti-inflammatory agent ketoprofen into self-assembling prodrugs that enable the effective purification of ketoprofen enantiomers, the improved selectivity and potency of ketoprofen, as well as the formation of one-component drug-bearing supramolecular hydrogels. We found that the ketoprofen hydrogelator could exhibit much-enhanced selectivity for cyclooxygenase 2 (COX-2) over COX-1, reduce the concentration of inflammatory cytokines (IL-1 and TNFα), and induce apoptosis in fibroblast-like synoviocytes while maintaining biocompatibility with healthy chondrocytes. In addition, these anti-inflammatory agent-containing hydrogels demonstrated the ability to retain the therapeutic within a joint cavity after intra-articular injection, exhibiting a slow, steady release into the plasma. We believe that upon further optimization these drug-based injectable supramolecular hydrogels could provide the basis for a local treatment strategy for rheumatoid arthritis and similar conditions.

Indexed as

AnimalsAnti-Inflammatory AgentsArthritis, RheumatoidCells, CulturedDrug CarriersFibroblastsHydrogelsInjections, Intra-ArticularKetoprofenRatsAnti-Inflammatory AgentsDrug CarriersHydrogelsKetoprofendrug deliverypeptide-drug conjugaterheumatoid arthritis.self-assemblysupramolecular hydrogel

Identifiers

PMID28656057
PMCPMC5485419
OpenAlexW2619399241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.