ReviewAnnals of gastroenterology2017
Iron deficiency anemia in chronic liver disease: etiopathogenesis, diagnosis and treatment.
Review in Annals of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04622449 (Assessment of Role of Iron Metabolism, Nutritional Deficiency, Gastrointestinal Loss, and Chronic Inflammation in the Etiopathogenesis of Anemia in Chronic Liver Disease), which is not on this map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Role of Iron Metabolism, Nutritional Deficiency, Gastrointestinal Loss, and Chronic Inflammation in the Etiopathogenesis of Anemia in Chronic Liver Disease
Who cites it
43 citing papers in PubMed, 116 citations in OpenAlex.
- Factors associated with major complications defined by Clavien-Dindo classification 3-5 after liver transplantation: a prospective multicenter cohort study.Frontiers in surgery · 2025Trial
- Risk factors associated with blood transfusion in liver transplantation.Scientific reports · 2024Trial
- Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.Aging clinical and experimental research · 2022Trial
- Intermittent oral administration of iron oxide nanoparticles modulates iron homeostasis, hematological, inflammatory, and organ-specific responses in iron-deficient rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Treatment of Hypovitaminosis D Is Associated with Improvement in Anemia of Inflammation in Patients with Decompensated Cirrhosis.Medical sciences (Basel, Switzerland) · 2026Article
- Serum biomarker analysis may guide management of anemia in patients with chronic liver disease.Frontiers in medicine · 2026Article
- Cross-Cancer Transfer Learning for Gastric Cancer Risk Prediction from Electronic Health Records.Diagnostics (Basel, Switzerland) · 2025Article
- Eryptosis in Liver Diseases: Contribution to Anemia and Hypercoagulation.Medical sciences (Basel, Switzerland) · 2025Review
- Prognostic value of liver outcome score and hemoglobin in autoimmune liver disease overlap syndromes.World journal of hepatology · 2025Article
- Predictors of survival in autoimmune liver disease overlap syndromes.World journal of hepatology · 2024Article
- Article
- Low Serum Soluble Transferrin Receptor Levels Are Associated with Poor Prognosis in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.Biological trace element research · 2023Article
- Review
- Patient Blood Management in Liver Transplant-A Concise Review.Biomedicines · 2023Review
- Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine.Clinical and experimental hepatology · 2023Article
- Red Blood Cell Alloimmunization and Its Associated Factors among Chronic Liver Disease Patients in a Teaching Hospital in Northeastern Malaysia.Diagnostics (Basel, Switzerland) · 2023Article
- Prevalence and Associated Factors of Anemia Among Hospital Admitted Patients in Eastern Ethiopia.Journal of blood medicine · 2023Article
- Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Differentiating between liver diseases by applying multiclass machine learning approaches to transcriptomics of liver tissue or blood-based samples.JHEP reports : innovation in hepatology · 2022Article
- Iron imbalance in cancer: Intersection of deficiency and overload.Cancer medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic liver disease is accompanied by multiple hematological abnormalities. Iron deficiency anemia is a frequent complication of advanced liver disease. The etiology is multifactorial, mostly due to chronic hemorrhage into the gastrointestinal tract. The diagnosis of iron deficiency anemia is very challenging, as simple laboratory methods, including serum iron, ferritin, transferrin saturation (Tsat), and mean corpuscular volume are affected by the liver disease itself or the cause of the disease, resulting in difficulty in the interpretation of the results. Several new parameters, such as red blood cell ferritin, serum transferrin receptor test and index, and hepcidin, have been studied for their utility in indicating true iron deficiency in combination with chronic liver disease. Once iron deficiency anemia is diagnosed, it should be treated with oral or parenteral iron as well as portal pressure reducing drugs. Blood transfusion is reserved for symptomatic anemia despite iron supplementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.