Evidence map›Paper›PMID 28655891›Full record

ArticleScientific reports2017

A Gelatin-sulfonated Silk Composite Scaffold based on 3D Printing Technology Enhances Skin Regeneration by Stimulating Epidermal Growth and Dermal Neovascularization.

Si Xiong, Xianzhu Zhang, Ping Lu, Yan Wu, Quan Wang, Heng Sun, Boon Chin Heng, Varitsara Bunpetch, Shufang Zhang, Hongwei Ouyang

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Silk Fibroin Particle-Laden Sponges as a Multiphase Controlled Release Platform.Regenerative engineering and translational medicine · 2025
    Article
  3. Article
  4. Organoids in skin wound healing.Burns & trauma · 2025
    Review
  5. 3D Printing-Based Hydrogel Dressings for Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  6. (3D) Bioprinting-Next Dimension of the Pharmaceutical Sector.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  7. Review
  8. Silk fibroin-based scaffolds for tissue engineering.Frontiers in bioengineering and biotechnology · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Engineered biomimetic micro/nano-materials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2023
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. 3D skin bioprinting: future potential for skin regeneration.Postepy dermatologii i alergologii · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Si XiongCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.
Xianzhu ZhangCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.
Ping LuCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.
Yan WuCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.
Quan WangCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0002-3082-5471
Heng SunCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.
Boon Chin HengUniversity of Hong Kong, Faculty of Dentistry, Pokfulam, Hong Kong SAR, China.
Varitsara BunpetchCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.
Shufang ZhangCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China. zhangshufang@zju.edu.cn.
Hongwei OuyangCenter for Stem Cell and Tissue Engineering, School of Medicine, Zhejiang University, Hangzhou, China.

Funding

Corticostriatal networks and NMDAR mediation of habitual and flexible actionK22AA020303 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRIGMAN, JONATHAN L · 2011 to 2013
$486k
NIAAA NIH HHS K22 AA020303
6 · The paper itself

Abstract

One of the key problems hindering skin repair is the deficiency of dermal vascularization and difficulty of epidermis regeneration, which makes it challenging to fabricate scaffolds that can biologically fulfill the requirements for skin regeneration. To overcome this problem, three-dimensional printing was used to fabricate a gelatin-sulfonated silk composite scaffold that was incorporated with basic fibroblast growth factor 2 (FGF-2) through binding with a sulfonic acid group (SO

Indexed as

Printing, Three-DimensionalRegenerationTissue EngineeringBiocompatible MaterialsCell LineDermisEpidermisFibroblast Growth Factor 2GelatinHumansNeovascularization, PhysiologicSilkSkinSkin Physiological PhenomenaSulfonic AcidsTissue ScaffoldsBiocompatible MaterialsFibroblast Growth Factor 2GelatinSilkSulfonic Acids

Identifiers

PMID28655891
PMCPMC5487355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.