ArticleScience signaling2017
In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells.
Open access · greenAbstract read
In one paragraph
Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- An Entropy-Based Approach to Model Selection with Application to Single-Cell Time-Stamped Snapshot Data.Entropy (Basel, Switzerland) · 2025Article
- Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review).Molecular medicine reports · 2025Review
- An Entropy-Based Approach to Model Selection with Application to Single-Cell Time-Stamped Snapshot Data.bioRxiv : the preprint server for biology · 2025Article
- NK cell-based immunotherapy strategies for myeloid leukemia.Frontiers in immunology · 2025Review
- NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells.Frontiers in immunology · 2025Article
- Natural killer cells in cancer immunotherapy.MedComm · 2024Review
- NK cell-based tumor immunotherapy.Bioactive materials · 2024Review
- Computational Methods for Single-Cell Proteomics.Annual review of biomedical data science · 2023Review
- McSNAC: A software to approximate first-order signaling networks from mass cytometry data.Quantitative biology (Beijing, China) · 2023Article
- Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion.The Journal of experimental medicine · 2022Article
- Contribution of natural killer cells in innate immunity against colorectal cancer.Frontiers in oncology · 2022Review
- NK cell receptor and ligand composition influences the clearance of SARS-CoV-2.The Journal of clinical investigation · 2021Article
- Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer.Nature communications · 2021Article
- Review
- NK cells for cancer immunotherapy.Nature reviews. Drug discovery · 2020Review
- Maximum Entropy Framework for Predictive Inference of Cell Population Heterogeneity and Responses in Signaling Networks.Cell systems · 2020Article
- Paving the Way Towards Universal Chimeric Antigen Receptor Therapy in Cancer Treatment: Current Landscape and Progress.Frontiers in immunology · 2020Review
- Harnessing the cDC1-NK Cross-Talk in the Tumor Microenvironment to Battle Cancer.Frontiers in immunology · 2020Review
- Understanding the Dynamics of T-Cell Activation in Health and Disease Through the Lens of Computational Modeling.JCO clinical cancer informatics · 2019Review
- Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Sayak MukherjeeBattelle Center for Mathematical Medicine, Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.ORCID http://orcid.org/0000-0002-1755-3328
Helle JensenDepartment of Microbiology and Immunology and Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID http://orcid.org/0000-0002-7446-7645
William StewartBattelle Center for Mathematical Medicine, Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
David StewartDepartment of Mathematics, University of Iowa, Iowa City, IA 52242, USA.
William C RayBattelle Center for Mathematical Medicine, Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Shih-Yu ChenDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Garry P NolanDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Lewis L LanierDepartment of Microbiology and Immunology and Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94143, USA. lewis.lanier@ucsf.edu das.70@osu.edu.ORCID http://orcid.org/0000-0003-1308-3952
Jayajit DasBattelle Center for Mathematical Medicine, Research Institute at the Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA. lewis.lanier@ucsf.edu das.70@osu.edu.ORCID http://orcid.org/0000-0001-9649-4698
Nationwide Children's Hospital · USParker Institute for Cancer Immunotherapy · USStanford University · USUniversity of Iowa · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MSystems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MNK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0MNK and T Cell Costimulation by NKG2D/DAP10R37AI066897 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2015
$3.8MBalanced signaling cues to guide cell transitions in the blood lineage continuumR01HL120724 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAKRABORTY, ARUP K., NOLAN, GARRY P · 2015 to 2019
$3.7MStanford Technology Accelerating Medicines Partnership CenterUH2AR067676 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H, UTZ, PAUL JOSEPH · 2014 to 2020
$2.6M(PQD2)New Biomarkers and Pathways to Enhance Cure in Ovarian CancersR01CA184968 · NCI · STANFORD UNIVERSITY · PI FANTL, WENDY JANE, SIKIC, BRANIMIR I · 2014 to 2017
$2.0MHighly multiplexed ion-beam tissue molecular imaging with sub-micron resolutionR33CA183654 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2014 to 2016
$1.2MIntegrating mass cytometric and transcriptomic profiles of solid tumorsR33CA183692 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISS, WILLIAM A · 2014 to 2016
$1.2MHighly multiplexed ion-beam tissue RNA in situ imaging with sub-micron resolutionR21CA183660 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BOROWSKY, ALEXANDER D, LEVENSON, RICHARD M. · 2014 to 2015
$539kUncovering Basic Signaling Mechanisms in NK Cells in Mice and HumansR56AI108880 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI DAS, JAYAJIT · 2014 to 2014
$455kNCI NIH HHS R01 CA184968NCI NIH HHS R21 CA183660NCI NIH HHS R33 CA183654NCI NIH HHS R33 CA183692NHLBI NIH HHS R01 HL120724NIAID NIH HHS R01 AI068129NIAID NIH HHS R37 AI066897NIAID NIH HHS R56 AI108880NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI100627NIAMS NIH HHS UH2 AR067676NIDDK NIH HHS P30 DK063720
Abstract
Natural killer (NK) cells perform immunosurveillance of virally infected and transformed cells, and their activation depends on the balance between signaling by inhibitory and activating receptors. Cytokine receptor signaling can synergize with activating receptor signaling to induce NK cell activation. We investigated the interplay between the signaling pathways stimulated by the cytokine interleukin-2 (IL-2) and the activating receptor NKG2D in immature (CD56
Indexed as
Gene Expression RegulationAnimalsCD56 AntigenCytokinesHumansInterferon-gammaInterleukin-2Killer Cells, NaturalLeukocyte Common AntigensLymphocyte ActivationMiceModels, TheoreticalNK Cell Lectin-Like Receptor Subfamily KSignal TransductionCD56 AntigenCytokinesInterferon-gammaInterleukin-2Leukocyte Common AntigensNCAM1 protein, humanNK Cell Lectin-Like Receptor Subfamily KPTPRC protein, humanPtprc protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.