Evidence map›Paper›PMID 28655843›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR.

Christian Sievert, Lizbeth M Nieves, Larry A Panyon, Taylor Loeffler, Chandler Morris, Reed A Cartwright, Xuan Wang

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 84 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
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  8. Article
  9. Article
  10. Engineering a SyntheticACS synthetic biology · 2024
    Article
  11. Review
  12. EngineeringMicroorganisms · 2023
    Article
  13. Review
  14. Xylose Isomerase Depletion Enhances Virulence ofInternational journal of molecular sciences · 2023
    Article
  15. Conversion ofMicroorganisms · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christian SievertSchool of Life Sciences, Arizona State University, Tempe, AZ 85287.
Lizbeth M NievesSchool of Life Sciences, Arizona State University, Tempe, AZ 85287.
Larry A PanyonSchool of Life Sciences, Arizona State University, Tempe, AZ 85287.
Taylor LoefflerSchool of Life Sciences, Arizona State University, Tempe, AZ 85287.
Chandler MorrisSchool of Life Sciences, Arizona State University, Tempe, AZ 85287.
Reed A CartwrightSchool of Life Sciences, Arizona State University, Tempe, AZ 85287; wangxuan@asu.edu cartwright@asu.edu.
Xuan WangSchool of Life Sciences, Arizona State University, Tempe, AZ 85287; wangxuan@asu.edu cartwright@asu.edu.
Arizona State University · US

Funding

Analysis of de novo mutation from sequencing of related individuals and cellsR01HG007178 · NHGRI · WASHINGTON UNIVERSITY · PI CONRAD, DONALD F. · 2014 to 2018
$2.6M
NHGRI NIH HHS R01 HG007178
6 · The paper itself

Abstract

Microbial production of fuels and chemicals from lignocellulosic biomass provides promising biorenewable alternatives to the conventional petroleum-based products. However, heterogeneous sugar composition of lignocellulosic biomass hinders efficient microbial conversion due to carbon catabolite repression. The most abundant sugar monomers in lignocellulosic biomass materials are glucose and xylose. Although industrial

Indexed as

Catabolite RepressionMutationBiological TransportCarbonDirected Molecular EvolutionDNA, BacterialEscherichia coliEscherichia coli ProteinsFermentationGenetic EngineeringGenome, BacterialGlucoseLactic AcidLigninMetabolic EngineeringMetabolismCarbonDNA, BacterialEscherichia coli ProteinsGlucoseLactic AcidLigninlignocelluloseSugarsTranscription FactorsXyloseXylR protein, E coliadaptive laboratory evolutioncarbon catabolite repressionE. colimetabolic engineeringXylR

Identifiers

PMID28655843
PMCPMC5514714
OpenAlexW2952470240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.