ArticleProceedings of the National Academy of Sciences of the United States of America2017
Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Assessing the reliability of cellular decision making from noisy, multidimensional single-cell TNF-NF-κB signaling data.PLoS computational biology · 2026Article
- Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity.Nature communications · 2025Article
- Systems Biology of the Cancer Cell.Annual review of biomedical engineering · 2025Review
- Model supports asymmetric regulation across the intercellular junction for collective cell polarization.PLoS computational biology · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Mesenchymal cell migration on one-dimensional micropatterns.Frontiers in cell and developmental biology · 2024Review
- On multistability and constitutive relations of cell motion on fibronectin lanes.Biophysical journal · 2023Article
- Biophysics involved in the process of tumor immune escape.iScience · 2022Review
- Oscillations and bifurcation structure of reaction-diffusion model for cell polarity formation.Journal of mathematical biology · 2022Article
- The biophysics of cancer: emerging insights from micro- and nanoscale tools.Advanced nanobiomed research · 2022Article
- Symmetry and fluctuation of cell movements in neural crest-derived facial mesenchyme.Development (Cambridge, England) · 2021Article
- Article
- Using Live-Cell Imaging and Synthetic Biology to Probe Directed Migration inFrontiers in cell and developmental biology · 2021Review
- Four different mechanisms for switching cell polarity.PLoS computational biology · 2021Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells.Biophysical journal · 2020Article
- Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.iScience · 2020Article
- Article
- A hybrid stochastic-deterministic mechanochemical model of cell polarization.Molecular biology of the cell · 2020Article
- Tuning Cell Motility via Cell Tension with a Mechanochemical Cell Migration Model.Biophysical journal · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
Cell polarization and directional cell migration can display random, persistent, and oscillatory dynamic patterns. However, it is not clear whether these polarity patterns can be explained by the same underlying regulatory mechanism. Here, we show that random, persistent, and oscillatory migration accompanied by polarization can simultaneously occur in populations of melanoma cells derived from tumors with different degrees of aggressiveness. We demonstrate that all of these patterns and the probabilities of their occurrence are quantitatively accounted for by a simple mechanism involving a spatially distributed, mechanochemical feedback coupling the dynamically changing extracellular matrix (ECM)-cell contacts to the activation of signaling downstream of the Rho-family small GTPases. This mechanism is supported by a predictive mathematical model and extensive experimental validation, and can explain previously reported results for diverse cell types. In melanoma, this mechanism also accounts for the effects of genetic and environmental perturbations, including mutations linked to invasive cell spread. The resulting mechanistic understanding of cell polarity quantitatively captures the relationship between population variability and phenotypic plasticity, with the potential to account for a wide variety of cell migration states in diverse pathological and physiological conditions.
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