Evidence map›Paper›PMID 28655769›Full record

ArticleThe Journal of biological chemistry2017

Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex.

Yang Gao, Gerwin Westfield, Jon W Erickson, Richard A Cerione, Georgios Skiniotis, Sekar Ramachandran

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. A rapid, tag-free way to purify functional GPCRs.The Journal of biological chemistry · 2024
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Structure and dynamics of GPCR signaling complexes.Nature structural & molecular biology · 2018
    Review
  11. Article
  12. Shining a light on GPCR complexes.The Journal of biological chemistry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yang GaoFrom the Department of Chemistry and Chemical Biology, Baker Laboratory, and Ithaca, New York 14853.
Gerwin WestfieldLife Sciences Institute and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109.
Jon W EricksonFrom the Department of Chemistry and Chemical Biology, Baker Laboratory, and Ithaca, New York 14853.
Richard A CerioneFrom the Department of Chemistry and Chemical Biology, Baker Laboratory, and Ithaca, New York 14853; Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853. Electronic address: rac1@cornell.edu.
Georgios SkiniotisLife Sciences Institute and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109.
Sekar RamachandranFrom the Department of Chemistry and Chemical Biology, Baker Laboratory, and Ithaca, New York 14853.

Funding

Overall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5M
Roles of Cdc42 and its signaling partners in cell growth and differentiationR01GM047458 · NIGMS · CORNELL UNIVERSITY ITHACA · PI CERIONE, RICHARD A. · 1992 to 2016
$5.6M
New frontiers in extracellular signalingR35GM122575 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2017 to 2021
$3.0M
Architectural Basis of Leptin Transmembrane SignalingR01DK090165 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2011 to 2017
$2.3M
NIDDK NIH HHS R01 DK090165NIGMS NIH HHS P41 GM103485NIGMS NIH HHS R01 GM047458NIGMS NIH HHS R35 GM122575
6 · The paper itself

Abstract

The visual photo-transduction cascade is a prototypical G protein-coupled receptor (GPCR) signaling system, in which light-activated rhodopsin (Rho*) is the GPCR catalyzing the exchange of GDP for GTP on the heterotrimeric G protein transducin (G

Indexed as

Models, MolecularAnimalsCattleCrystallography, X-RayDetergentsEye ProteinsGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsLightMicroscopy, ElectronPeptide FragmentsProtein ConformationProtein MultimerizationProtein StabilityRecombinant Fusion ProteinsRetinaDetergentsEye ProteinsGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsPeptide FragmentsRecombinant Fusion ProteinsRhodopsinTransducin7-helix receptorEMG-proteinG protein-coupled receptor (GPCR)photo-transductionrhodopsinSAXSsignal transductionstructural biologytransducin

Identifiers

PMID28655769
PMCPMC5572916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.