Evidence map›Paper›PMID 28655457›Full record

ReviewBrazilian journal of anesthesiology (Elsevier)

[Occupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gases].

Lorena M C Lucio, Mariana G Braz, Paulo do Nascimento Junior, José Reinaldo C Braz, Leandro G Braz

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Bibliometric analysis of occupational exposure in operating room from 1973 to 2022.Journal of occupational medicine and toxicology (London, England) · 2024
    Article
  8. Article
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  10. Review
  11. Article
  12. Article
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  15. Article
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  18. Pro-Con Debate: Nitrous Oxide for Labor Analgesia.BioMed research international · 2019
    Review
  19. Review
  20. Paving the way to environment-friendly greener anesthesia.Journal of anaesthesiology, clinical pharmacology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lorena M C LucioUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, Botucatu, SP, Brasil.
Mariana G BrazUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, Botucatu, SP, Brasil. Electronic address: mgbraz@hotmail.com.
Paulo do Nascimento JuniorUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, Botucatu, SP, Brasil.
José Reinaldo C BrazUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, Botucatu, SP, Brasil.
Leandro G BrazUniversidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, Botucatu, SP, Brasil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss occupational exposure to WAGs and its impact on exposed professionals, with emphasis on genetic damage and oxidative stress. CONTENT: Despite the emergence of safer inhaled anesthetics, occupational exposure to WAGs remains a current concern. Factors related to anesthetic techniques and anesthesia workstations, in addition to the absence of a scavenging system in the OR, contribute to anesthetic pollution. In order to minimize the health risks of exposed professionals, several countries have recommended legislation with maximum exposure limits. However, developing countries still require measurement of WAGs and regulation for occupational exposure to WAGs. WAGs are capable of inducing damage to the genetic material, such as DNA damage assessed using the comet assay and increased frequency of micronucleus in professionals with long-term exposure. Oxidative stress is also associated with WAGs exposure, as it induces lipid peroxidation, oxidative damage in DNA, and impairment of the antioxidant defense system in exposed professionals.

conclusionsThe occupational hazards related to WAGs including genotoxicity, mutagenicity and oxidative stress, stand as a public health issue and must be acknowledged by exposed personnel and responsible authorities, especially in developing countries. Thus, it is urgent to stablish maximum safe limits of concentration of WAGs in ORs and educational practices and protocols for exposed professionals.

Indexed as

DNA DamageOperating RoomsAir Pollutants, OccupationalAir Pollution, IndoorAnesthetics, InhalationHumansOccupational ExposureOxidative StressAir Pollutants, OccupationalAnesthetics, InhalationAnestésicos inalatóriosEnvironment pollutionEstresse oxidativoExposição ocupacionalGenomic instabilityGenotoxicity testingInhaled anestheticsInstabilidade genômicaOccupational exposureOxidative stressPoluição ambientalTestes de genotoxicidade

Identifiers

PMID28655457
PMCPMC9391701
OpenAlexW2636121829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.