Evidence map›Paper›PMID 28655143›Full record

ReviewAmerican journal of hypertension2017

Air Pollution and Cardiometabolic Disease: An Update and Call for Clinical Trials.

Robert D Brook, David E Newby, Sanjay Rajagopalan

Registry-linked trialAbstract readReview
In one paragraph

Review in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04908917 (Reducing AIR Pollution Exposure to Lower Blood PRESSURE), which is not on this map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04908917 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Reducing AIR Pollution Exposure to Lower Blood PRESSURE

TypeinterventionalSponsorWayne State UniversityRan2021 to 2023Enrolled200ConditionsMild Hypertension, Air Pollution ExposureArmsPortable Air Cleaner with a HEPA Filter, Portable Air Cleaner without a HEPA Filter
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Atmospheric stressors and kidney diseases.Nature reviews. Nephrology · 2026
    Review
  8. Article
  9. PMEnvironment & health (Washington, D.C.) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Cardiovascular Emergency Hospitalization Risks of PMEnvironment & health (Washington, D.C.) · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert D BrookDivision of Cardiovascular Medicine, University of Michigan, USA.
David E NewbyBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, United Kingdom.
Sanjay RajagopalanDivision of Cardiovascular Medicine, Harrington Heart and Vascular Institute, University Hospitals, USA.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Air Pollution and Hypertension: Vascular MechanismsR01ES015146 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAJAGOPALAN, SANJAY · 2007 to 2018
$4.5M
Medical Research Council G0701127NIDDK NIH HHS P30 DK020572NIEHS NIH HHS R01 ES015146
6 · The paper itself

Abstract

Fine particulate matter <2.5 µm (PM2.5) air pollution is a leading cause of global morbidity and mortality. The largest portion of deaths is now known to be due to cardiovascular disorders. Several air pollutants can trigger acute events (e.g., myocardial infarctions, strokes, heart failure). However, mounting evidence additionally supports that longer-term exposures pose a greater magnified risk to cardiovascular health. One explanation may be that PM2.5 has proven capable of promoting the development of chronic cardiometabolic conditions including atherosclerosis, hypertension, and diabetes mellitus. Here, we provide an updated overview of recent major studies regarding the impact of PM2.5 on cardiometabolic health and outline key remaining scientific questions. We discuss the relevance of emerging trials evaluating personal-level strategies (e.g., facemasks) to prevent the harmful effects of PM2.5, and close with a call for large-scale outcome trials to allow for the promulgation of formal evidence-base recommendations regarding their appropriate usage in the global battle against air pollution.

Indexed as

Air PollutionCardiovascular DiseasesClinical Trials as TopicHumansMetabolic DiseasesParticulate MatterParticulate Matterblood pressurecardiovasculardiabetes mellitushypertensionmorbiditypollutantsprevention

Identifiers

PMID28655143
PMCPMC5861586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.