Evidence map›Paper›PMID 28654921›Full record

Observational studyInternational archives of allergy and immunology2017

Effect of Maternal Dietary Patterns during Pregnancy on Self-Reported Allergic Diseases in the First 3 Years of Life: Results from the GUSTO Study.

Evelyn Xiu Ling Loo, Lynn Ong, Anne Goh, Ai-Ru Chia, Oon Hoe Teoh, Marjorelee T Colega, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D Gluckman and 6 more

Abstract readObservational Study
In one paragraph

Observational study in International archives of allergy and immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Pooled it
  3. Review
  4. Review
  5. Allergic rhinitis and asthma: drivers of otitis media and associated tympanostomy tube placement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  6. Article
  7. Observational
  8. Review
  9. Review
  10. Article
  11. Article
  12. Role of maternal tryptophan metabolism in allergic diseases in the offspring.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Article
  13. Article
  14. Article
  15. Nutritional Issues in Food Allergy.Clinical reviews in allergy & immunology · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Evelyn Xiu Ling LooSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Lynn Ong
Anne Goh
Ai-Ru Chia
Oon Hoe Teoh
Marjorelee T Colega
Yiong Huak Chan
Seang Mei Saw
Kenneth Kwek
Peter D Gluckman
Keith M Godfrey
Hugo Van Bever
Bee Wah Lee
Yap Seng Chong
Mary Foong-Fong Chong
Lynette Pei-Chi Shek
National University of Singapore · SGAgency for Science, Technology and Research · SGKK Women's and Children's Hospital · SGNational University Health System · SGNIHR Southampton Biomedical Research Centre · GBSingapore Institute for Clinical Sciences · SG

Funding

Medical Research Council MC_U147574222Medical Research Council MC_U147574226Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/4Medical Research Council MR/J000094/1
6 · The paper itself

Abstract

backgroundMaternal diet during pregnancy has been suggested to be an important early-life exposure that influences immune tolerance and the development of allergic diseases in offspring.

methodsWe examined the relationship between maternal dietary patterns assessed using 24-h recalls and food diaries at 26-28 weeks of pregnancy and the subsequent development of allergic outcomes in the offspring in the Growing Up in Singapore towards Healthy Outcomes (GUSTO) birth cohort. Exploratory factor analysis was used to characterize maternal dietary patterns during pregnancy. During repeated visits in the first 36 months of life, questionnaires were administered to ascertain allergic symptoms, namely, eczema, rhinitis, and wheeze. At ages 18 and 36 months, we administered skin-prick testing to inhalant and food allergens.

resultsOf the 3 maternal dietary patterns that emerged, the seafood and noodles pattern was associated with a reduced risk of developing allergen sensitization at both 18 months (odds ratio [95% confidence interval]: 0.7 [0.5-0.9]) and 36 months (0.7 [0.6-0.9]) after adjustment for a family history of allergy, and ethnicity, sex, and maternal education levels. No associations between the patterns vegetables, fruit, and white rice or pasta, cheese, and processed meat were observed with any of the allergic outcomes in the first 18 and 36 months of life.

conclusionMaternal diet during pregnancy can influence the subsequent development of allergic outcomes in offspring.

Indexed as

DietMaternal Nutritional Physiological PhenomenaPrenatal Exposure Delayed EffectsChild, PreschoolCohort StudiesFemaleHumansHypersensitivityInfantMaleOdds RatioPregnancySelf ReportSingaporeSurveys and QuestionnairesAllergic diseasesBirth cohortsMaternal dietary patternsPregnancy

Identifiers

PMID28654921
PMCPMC5531258
OpenAlexW2611468682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.