ReviewNMR in biomedicine2019
Building connectomes using diffusion MRI: why, how and but.
Review in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
156 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- An MRI-Based, Data-Driven Model of Cortical Laminar Connectivity.Neuroinformatics · 2021Pooled it
- The structural connectome in traumatic brain injury: A meta-analysis of graph metrics.Neuroscience and biobehavioral reviews · 2019Pooled it
- Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis.Frontiers in immunology · 2019Trial
- Structural Connectivity of Functionally Defined Episodic Memory Networks: A Large-Scale Connectome-Behavior Study.Brain and behavior · 2026Article
- Mapping the spatiotemporal continuum of structural connectivity development across the human connectome in youth.Nature communications · 2026Article
- Structural connectome changes as biomarkers of stroke recovery: a longitudinal 7T MRI study.BMC neuroscience · 2026Article
- General cognitive function and the brain's structural connectome.bioRxiv : the preprint server for biology · 2026Article
- A pilot study on protocol consistency and graph metric reproducibility in microstructure-weighted connectomes.Scientific reports · 2026Article
- Loss of microstructural integrity in left hemispheric white matter tracts is associated with poorer digits in noise understanding.GeroScience · 2026Article
- Does white matter structure relate to hemispheric language lateralization? A systematic review.Brain communications · 2026Review
- Study of sex differences in the whole brain white matter using diffusion MRI tractography and suprathreshold fiber cluster statistics.NeuroImage. Clinical · 2026Article
- Benchmarking overlapping community detection methods for applications in human connectomics.Network neuroscience (Cambridge, Mass.) · 2026Article
- Mind the brain age: How segmentation and template selection reshape structural connectomes.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline.Communications medicine · 2025Article
- Study of Sex Differences in the Whole Brain White Matter Using Diffusion MRI Tractography and Suprathreshold Fiber Cluster Statistics.bioRxiv : the preprint server for biology · 2025Article
- White Matter Networks of Phonological Awareness in Chinese Readers.Brain and behavior · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Review
- Harmonization of Structural Brain Connectivity Through Distribution Matching.Human brain mapping · 2025Article
- Animal models are useful in studying human neuroanatomy with tractography.Brain structure & function · 2025Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, fiber tracking algorithms and other methodological choices affect connectome estimation? What are the main factors that dictate the success and failure of connectome reconstruction? These are some of the key questions that we aim to address in this review. We provide an overview of the key methods that can be used to estimate the nodes and edges of macroscale connectomes, and we discuss open problems and inherent limitations. We argue that diffusion MRI-based connectome mapping methods are still in their infancy and caution against blind application of deep white matter tractography due to the challenges inherent to connectome reconstruction. We review a number of studies that provide evidence of useful microstructural and network properties that can be extracted in various independent and biologically relevant contexts. Finally, we highlight some of the key deficiencies of current macroscale connectome mapping methodologies and motivate future developments.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.